Evidence map›Paper›PMID 42142351›Full record

ArticleFetal diagnosis and therapy2026

Ventricle Width and Cerebrospinal Fluid Diversion Rate after Open Fetal Spina Bifida Repair: A 4-Year Follow-Up.

Julia Wawrla-Zepf, Ladina Rüegg, Martin Meuli, Luca Mazzone, Ueli Moehrlen, Sandra Fernandes Dias, Jenny C Kienzler, Nicole Ochsenbein-Kölble, Ladina Vonzun

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Article in Fetal diagnosis and therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Julia Wawrla-ZepfDepartment of Obstetrics, University Hospital Zurich, Zurich, Switzerland, julia.zepf@usz.ch.
Ladina RüeggDepartment of Obstetrics, University Hospital Zurich, Zurich, Switzerland.
Martin MeuliUniversity of Zurich, Zurich, Switzerland.
Luca MazzoneUniversity of Zurich, Zurich, Switzerland.
Ueli MoehrlenUniversity of Zurich, Zurich, Switzerland.
Sandra Fernandes DiasDivision of Pediatric Neurosurgery, University Children's Hospital Zurich-Eleonore Foundation, Zurich, Switzerland.
Jenny C KienzlerUniversity of Zurich, Zurich, Switzerland.
Nicole Ochsenbein-KölbleDepartment of Obstetrics, University Hospital Zurich, Zurich, Switzerland.
Ladina VonzunDepartment of Obstetrics, University Hospital Zurich, Zurich, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe objective of this study was to assess the postnatal cerebrospinal fluid diversion (CSFD) rates and associated prenatal risk factors (RFs) in patients with open fetal spina bifida (fSB) repair over a 4-year follow-up.

methodsIn 185 patients, CSFD rate was determined at 1 year and incremental risk (IR) for CSFD at 2 and 4 years. Characteristics of children without CSFD were compared to those with CSFD, and multiple regression analysis evaluated RF.

resultsSixty-four children (35%) needed CSFD within the first year. These children had larger head circumference (HC) at screening (p = 0.001) and before delivery (p < 0.001) and larger ventricles at screening (Vp screening) and before delivery (Vp delivery) (each p < 0.001). Multiple regression identified only Vp screening, Vp delivery, and their delta as independent RF for CSFD. Vp values were higher in children needing CSFD within the first year compared with years 2-4 (p < 0.001 and p = 0.01), and larger Vp was associated with earlier CSFD in the first year (p = 0.02). IR for CSFD declined over follow-up.

conclusionThe 1-year CSFD rate after open fSB repair was 35%, with decreasing IR through year four. Larger Vp at screening, before delivery, and their delta were independent RF for CSFD, while HC was not.

Indexed as

Cerebral ventricle widthCerebrospinal fluid diversionFetal surgeryShunt rateSpina bifida

Identifiers

PMID42142351
PMCPMC13372279

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