Evidence map›Paper›PMID 42142240›Full record

ArticleProbiotics and antimicrobial proteins2026

Food-Derived Limosilactobacillus fermentum GR-3 Enhances Anti-PD-1 Immunotherapy Efficacy.

Wei Xiang, Qi Yang, Jing Ji, Hui Qiao, Aman Khan, El-Sayed Salama, Chunlan Mao, Ying Wu, Xiangkai Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Probiotics and antimicrobial proteins, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. The Role ofInternational journal of molecular sciences · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Wei XiangMinistry Key Laboratory of Cell Activities and Stress Adaptations, School of Life Sciences, Lanzhou University, Lanzhou, Gansu Province, 730000, China.
Qi YangMinistry Key Laboratory of Cell Activities and Stress Adaptations, School of Life Sciences, Lanzhou University, Lanzhou, Gansu Province, 730000, China.
Jing JiMinistry Key Laboratory of Cell Activities and Stress Adaptations, School of Life Sciences, Lanzhou University, Lanzhou, Gansu Province, 730000, China.
Hui QiaoDepartment of Oncology, The First Hospital of Lanzhou University, Lanzhou, Gansu Province, 730000, China.
Aman KhanCollege of Life Science, Northeast Forestry University, Harbin, Harbin Province, 150040, China.
El-Sayed SalamaDepartment of Occupational and Environmental Health, School of Public Health, Lanzhou University, Lanzhou, Gansu Province, 730000, China.
Chunlan MaoMinistry Key Laboratory of Cell Activities and Stress Adaptations, School of Life Sciences, Lanzhou University, Lanzhou, Gansu Province, 730000, China. maocl@lzu.edu.cn.
Ying WuMinistry Key Laboratory of Cell Activities and Stress Adaptations, School of Life Sciences, Lanzhou University, Lanzhou, Gansu Province, 730000, China. ywu18@lzu.edu.cn.
Xiangkai LiMinistry Key Laboratory of Cell Activities and Stress Adaptations, School of Life Sciences, Lanzhou University, Lanzhou, Gansu Province, 730000, China.

Funding

Gansu Province Science and Technology Major Project 24ZDWA005National Natural Science Foundation of China 32370110The Postdoctoral Fellowship Program of CPSF GZC20251840
6 · The paper itself

Abstract

Immune checkpoint blockade (ICB) has improved the cancer treatment, its application remains constrained by heterogeneous response rates and immune-related adverse events. While gut microbiome modulation represents a promising avenue to optimize ICB, rationally selected probiotics with defined mechanistic actions are critically lacking. Here, we selected Lactobacillus fermentum GR-3 (L. fermentum GR-3), a food-derived strain pre-screened for exceptional gastrointestinal resilience (maintaining > 10

Indexed as

Colorectal NeoplasmsImmune Checkpoint InhibitorsImmunotherapyLimosilactobacillus fermentumProbioticsProgrammed Cell Death 1 ReceptorAnimalsFemaleGastrointestinal MicrobiomeMiceMice, Inbred C57BLTumor MicroenvironmentImmune Checkpoint InhibitorsProgrammed Cell Death 1 ReceptorImmune checkpoint blockadeImmune homeostasisL. fermentum GR-3Short-chain fatty acids (SCFAs)Tumor microenvironment

Identifiers

PMID42142240
PMCPMC13518518

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.