Evidence map›Paper›PMID 42142161›Full record

ArticleInternational urogynecology journal2026

Low-Intensity Extracorporeal Shock Wave Therapy Restores Passive Urethral Closure Mechanism in Vaginal Distension Rat Model.

Takahiro Akimoto, Asuka Ashikari, Masahiro Kurobe, Gakuya Takamatsu, Yoshiyuki Akiyama, Haruki Kume, Minoru Miyazato

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Article in International urogynecology journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Takahiro AkimotoDepartment of Systems Physiology, Graduate School of Medicine, University of the Ryukyus, 1046 Kiyuna, Ginowan, Okinawa, 901-2720, Japan.
Asuka AshikariDepartment of Urology, University of the Ryukyus Hospital, Okinawa, Japan.
Masahiro KurobeDepartment of Systems Physiology, Graduate School of Medicine, University of the Ryukyus, 1046 Kiyuna, Ginowan, Okinawa, 901-2720, Japan.
Gakuya TakamatsuDepartment of Molecular and Cellular Physiology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.
Yoshiyuki AkiyamaDepartment of Urology, Shinshu University School of Medicine, Nagano, Japan.
Haruki KumeDepartment of Urology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Minoru MiyazatoDepartment of Systems Physiology, Graduate School of Medicine, University of the Ryukyus, 1046 Kiyuna, Ginowan, Okinawa, 901-2720, Japan. miyaz929@cs.u-ryukyu.ac.jp.ORCID http://orcid.org/0000-0003-3669-4510

Funding

Japan Society for the Promotion of Science 20K11158Japan Society for the Promotion of Science 22K11420Japan Society for the Promotion of Science 25K14404Japan Society for the Promotion of Science 25K14507
6 · The paper itself

Abstract

introduction and hypothesisLow-intensity extracorporeal shock wave therapy (LiESWT) is a promising noninvasive therapy for stress urinary incontinence (SUI). We assessed whether LiESWT restores urethral function in a vaginal distension (VD)-induced rat model of SUI, focusing on pelvic floor tissue remodeling and endoplasmic reticulum stress pathway as potential mechanisms.

methodsEighty-one female Sprague-Dawley rats underwent functional and tissue analyses. Sneezing was induced to assess urethral pressure responses. Leak point pressure (LPP) was measured with or without hypogastric and pudendal nerve transections. Tissue remodeling and molecular pathways were assessed using histological and molecular expression analyses.

resultsIn VD rats, baseline urethral pressure (9.9 ± 4.3 vs 17.6 ± 3.1 cmH

conclusionsLiESWT enhanced urethral function in the VD-induced SUI model by potentially facilitating pelvic floor tissue remodeling, thereby restoring passive urethral closure. The absence of sustained PERK activation in the late phase indicates the safety of LiESWT for SUI.

Indexed as

Extracorporeal Shockwave TherapyUrethraUrinary Incontinence, StressVaginaAnimalsDisease Models, AnimalEndoplasmic Reticulum StressFemalePressureRatsRats, Sprague-DawleySneezingEndoplasmic reticulum stressLeak point pressureLow-intensity extracorporeal shockwave therapyStress urinary incontinenceVaginal distension

Identifiers

PMID42142161

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.