ArticleACS chemical biology2026
Design, Synthesis, and Evaluation of a Novel Phenanthrene Derivative as a Potential DNA Intercalator.
Ghada Bouz, Giulia Quaglia, Loredana Latterini, Pavel Barta, Ondřej Jand'ourek, Klára Konečná, Jan Ősterreicher, Lieve Naesens, Leentje Persoons, Jan Storch and 1 more
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In one paragraphArticle in ACS chemical biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
11 authors.
Ghada BouzResearch Group of Advanced Materials and Organic Synthesis, Institute of Chemical Process Fundamentals of the Czech Academy of Sciences, Rozvojova 1/135, Prague 6165 00, Czech Republic.ORCID 0000-0003-2024-5788 Giulia QuagliaNano4Light Lab, Department of Chemistry, Biology and Biotechnology, University of Perugia, via Elce di Sotto 8, Perugia06123, Italy.
Loredana LatteriniNano4Light Lab, Department of Chemistry, Biology and Biotechnology, University of Perugia, via Elce di Sotto 8, Perugia06123, Italy.ORCID 0000-0002-1021-9423 Pavel BartaFaculty of Pharmacy in Hradec Králové, Charles University, Hradec Králové500 03, Czech Republic.
Ondřej Jand'ourekFaculty of Pharmacy in Hradec Králové, Charles University, Hradec Králové500 03, Czech Republic.ORCID 0000-0003-4633-2062 Klára KonečnáFaculty of Pharmacy in Hradec Králové, Charles University, Hradec Králové500 03, Czech Republic.
Jan ŐsterreicherFaculty of Pharmacy in Hradec Králové, Charles University, Hradec Králové500 03, Czech Republic.
Lieve NaesensKU Leuven , Department of Microbiology, Immunology and Transplantation, Rega Institute, LeuvenBE-3000, Belgium.ORCID 0000-0001-9742-9302 Leentje PersoonsKU Leuven , Department of Microbiology, Immunology and Transplantation, Rega Institute, LeuvenBE-3000, Belgium.
Jan StorchResearch Group of Advanced Materials and Organic Synthesis, Institute of Chemical Process Fundamentals of the Czech Academy of Sciences, Rozvojova 1/135, Prague 6165 00, Czech Republic.
Illia PanovResearch Group of Advanced Materials and Organic Synthesis, Institute of Chemical Process Fundamentals of the Czech Academy of Sciences, Rozvojova 1/135, Prague 6165 00, Czech Republic.
Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
Novel DNA intercalators are crucial for developing new pharmacologically active agents, such as chemotherapeutics, and advanced probes for cell labeling and imaging. Herein, we report the design and two-step synthesis of a novel phenanthrene-based derivative bearing cytosine moieties (PHE-CYT-3,6-TFA), formulated as a trifluoroacetic acid salt to enhance water solubility.
Indexed as
DNADrug DesignIntercalating AgentsPhenanthrenesAntineoplastic AgentsHumansMolecular Docking SimulationAntineoplastic AgentsDNAIntercalating AgentsphenanthrenePhenanthrenes
Identifiers
PMID42142021
PMCPMC13288466
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