Evidence map›Paper›PMID 42141999›Full record

ArticleThe veterinary quarterly2026

Magnetic nanohydroxyapatite-peptide silk fibroin hydrogel induces osteogenesis in canine periodontal ligament stem cells revealed by proteomic analysis.

Steven Dwi Purbantoro, Marta Scatena, Teeanutree Taephatthanasagon, Watchareewan Rodprasert, Poorichaya Somparn, Saharat Nanthawong, Jiradej Makjaroen, Pongsakorn Jantaratana, Rangsini Mahanonda, Noppadol Sa-Ard-Iam and 4 more

Abstract read
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In one paragraph

Article in The veterinary quarterly, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Steven Dwi PurbantoroThe International Graduate Program of Veterinary Science and Technology (VST), Faculty of Veterinary Science, Chulalongkorn University, Bangkok, Thailand.
Marta ScatenaDepartment of Bioengineering, University of Washington, Seattle, WA, USA.
Teeanutree TaephatthanasagonVeterinary Stem Cell and Bioengineering Innovation Center (VSCBIC), Faculty of Veterinary Science, Chulalongkorn University, Bangkok, Thailand.
Watchareewan RodprasertVeterinary Stem Cell and Bioengineering Innovation Center (VSCBIC), Faculty of Veterinary Science, Chulalongkorn University, Bangkok, Thailand.
Poorichaya SomparnCenter of Excellence in Systems Biology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Saharat NanthawongCenter of Excellence in Systems Biology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Jiradej MakjaroenCenter of Excellence in Systems Biology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Pongsakorn JantaratanaDepartment of Physics, Faculty of Science, Kasetsart University, Bangkok, Thailand.
Rangsini MahanondaImmunology Research Center, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand.
Noppadol Sa-Ard-IamImmunology Research Center, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand.
Thanaphum OsathanonDepartment of Anatomy, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand.
Sirinun Pisamai TabtieangDepartment of Surgery, Faculty of Veterinary Science, Chulalongkorn University, Bangkok, Thailand.
Chenphop SawangmakeVeterinary Stem Cell and Bioengineering Innovation Center (VSCBIC), Faculty of Veterinary Science, Chulalongkorn University, Bangkok, Thailand.
Sirirat RattanapuchpongVeterinary Stem Cell and Bioengineering Innovation Center (VSCBIC), Faculty of Veterinary Science, Chulalongkorn University, Bangkok, Thailand.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The architecture of bone defects presents a challenge in designing scaffolds that support structural integrity and enhance osteoinduction. To address this, a noninvasive injectable silk fibroin (SF)-based hydrogel incorporating magnetic nanohydroxyapatite (MHAp) and osteogenic growth peptide (OGP) was developed. This study investigated the osteogenic differentiation potential of the hydrogel and its underlying mechanism on canine periodontal ligament stem cells (cPDLSCs). The incorporation of MHAp and/or OGP significantly enhanced osteogenic differentiation as evidenced by increased alkaline phosphatase activity, osteogenic marker expression, and biomineralization. Proteomics analysis revealed that TGF-β, BMP, and Notch signaling pathways were involved in hydrogel-induced osteogenic differentiation, which was further validated by an inhibition assay. Overall, the injectable SF hydrogel containing MHAp and OGP demonstrates strong potential for clinical application in the treatment of alveolar bone defects.

Indexed as

DurapatiteFibroinsHydrogelsOsteogenesisPeriodontal LigamentStem CellsAnimalsCell DifferentiationCells, CulturedDogsProteomicsDurapatiteFibroinsHydrogelsAlveolar bone defectbone regenerationcanine periodontal ligament stem cells (cPDLSCs)injectable hydrogelmagnetic nanohydroxyapatite (MHAp)osteogenic growth peptide (OGP)proteomicssilk fibroin (SF)

Identifiers

PMID42141999
PMCPMC13182179

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.