Evidence map›Paper›PMID 42141809›Full record

ArticleOncoimmunology2026

An orthotopic organoid-based model to study early CD8⁺ T cell dysfunction and immunotherapy response in colorectal cancer.

Lorenzo Lucantonio, Ludovica Schiano, Francesca Sozio, Andrea Kosta, Giovanna Peruzzi, Rosa Molfetta, Giuseppe Pietropaolo, Mattia Laffranchi, Antonio Francesco Campese, Giovanni Bernardini and 6 more

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In one paragraph

Article in Oncoimmunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Lorenzo LucantonioDepartment of Molecular Medicine, Sapienza University of Rome, Rome, Italy.
Ludovica SchianoDepartment of Molecular Medicine, Sapienza University of Rome, Rome, Italy.
Francesca SozioDepartment of Molecular Medicine, Sapienza University of Rome, Rome, Italy.
Andrea KostaDepartment of Molecular Medicine, Sapienza University of Rome, Rome, Italy.
Giovanna PeruzziCentre For Life Nano- & Neuro-Science, Fondazione Istituto Italiano Di Tecnologia (IIT), Rome, Italy.
Rosa MolfettaDepartment of Molecular Medicine, Sapienza University of Rome, Rome, Italy.
Giuseppe PietropaoloDepartment of Molecular Medicine, Sapienza University of Rome, Rome, Italy.
Mattia LaffranchiDepartment of Molecular Medicine, Sapienza University of Rome, Rome, Italy.
Antonio Francesco CampeseDepartment of Molecular Medicine, Sapienza University of Rome, Rome, Italy.
Giovanni BernardiniDepartment of Molecular Medicine, Sapienza University of Rome, Rome, Italy.
Silvano SozzaniDepartment of Molecular Medicine, Sapienza University of Rome, Rome, Italy.
Angela GismondiDepartment of Molecular Medicine, Sapienza University of Rome, Rome, Italy.
Angela SantoniDepartment of Molecular Medicine, Sapienza University of Rome, Rome, Italy.
Giuseppe SciumèDepartment of Molecular Medicine, Sapienza University of Rome, Rome, Italy.
Stabile HelenaDepartment of Molecular Medicine, Sapienza University of Rome, Rome, Italy.
Cinzia FiondaDepartment of Molecular Medicine, Sapienza University of Rome, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Colorectal cancer (CRC) treatment represents a major clinical challenge, with immunotherapy providing durable responses only in a minority of patients. A deeper understanding of CD8⁺ T cell exhaustion and its contribution to immune checkpoint inhibitor (ICI) responsiveness is essential for the development of more effective therapeutic strategies. Preclinical models that faithfully reproduce the immune landscape of human CRC are therefore critical to address these challenges. Here, we established a syngeneic organoid-based orthotopic CRC mouse model by transplanting quadruple mutant

Indexed as

CD8-Positive T-LymphocytesColorectal NeoplasmsImmune Checkpoint InhibitorsImmunotherapyOrganoidsAnimalsDisease Models, AnimalHumansMiceMice, Inbred C57BLProgrammed Cell Death 1 ReceptorT-Cell ExhaustionImmune Checkpoint InhibitorsProgrammed Cell Death 1 ReceptorCD8+ T cell exhaustionColorectal cancerimmunotherapy

Identifiers

PMID42141809
PMCPMC13182965

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.