Evidence map›Paper›PMID 42141780›Full record

ArticlePest management science2026

Design, synthesis, and quantitative structure-antifungal activity relationship of 1,2,4-oxadiazole-containing mappicine derivatives against phytopathogenic fungi.

Yining Lei, Chunxia Chen, Lihong Fan, Hanbao Zhang, Xinyu Zhou, Zhonghui Sun, Gongyuan Zhao, Lianxu Shi, Jinsong Peng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pest management science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yining LeiCollege of Chemistry, Chemical Engineering and Resource Utilization, Northeast Forestry University, Harbin, P. R. China.ORCID https://orcid.org/0009-0003-6688-585X
Chunxia ChenCollege of Chemistry, Chemical Engineering and Resource Utilization, Northeast Forestry University, Harbin, P. R. China.
Lihong FanCollege of Chemistry, Chemical Engineering and Resource Utilization, Northeast Forestry University, Harbin, P. R. China.ORCID https://orcid.org/0009-0005-0237-0720
Hanbao ZhangCollege of Chemistry, Chemical Engineering and Resource Utilization, Northeast Forestry University, Harbin, P. R. China.ORCID https://orcid.org/0009-0005-5671-1981
Xinyu ZhouCollege of Chemistry, Chemical Engineering and Resource Utilization, Northeast Forestry University, Harbin, P. R. China.
Zhonghui SunCollege of Chemistry, Chemical Engineering and Resource Utilization, Northeast Forestry University, Harbin, P. R. China.
Gongyuan ZhaoCollege of Chemistry, Chemical Engineering and Resource Utilization, Northeast Forestry University, Harbin, P. R. China.
Lianxu ShiCollege of Chemistry, Chemical Engineering and Resource Utilization, Northeast Forestry University, Harbin, P. R. China.
Jinsong PengCollege of Chemistry, Chemical Engineering and Resource Utilization, Northeast Forestry University, Harbin, P. R. China.

Funding

Fundamental Research Funds for the Central Universities 2572023CT12National Key Research and Development Program of China 2024YFD2200804-2National Natural Science Foundation of China 32370413Natural Science Foundation of Heilongjiang Province ZD2025C006
6 · The paper itself

Abstract

backgroundFungal diseases in crops have become a growing major threat to global agriculture, causing substantial yield and economic losses. To address the critical demand for effective antifungal agents against phytopathogenic fungi, a series of mappicine derivatives incorporating a 1,2,4-oxadiazole moiety were rationally designed and synthesized in this study using an active substructure fusion strategy, followed by systematic evaluation of their antifungal potential.

resultsBioassay results revealed that most derivatives exhibited broad-spectrum and potent antifungal activity, with exceptional efficacy against Rhizoctonia solani (R. solani). Among them, compound M-25 displayed the strongest antifungal activity against R. solani with an EC

conclusionThis study offers valuable insights for the development of mappicine-based antifungal agents for plant protection. © 2026 Society of Chemical Industry.

Indexed as

Antifungal AgentsFungicides, IndustrialOxadiazolesPlant DiseasesRhizoctoniaDrug DesignQuantitative Structure-Activity Relationship1,2,4-oxadiazoleAntifungal AgentsFungicides, IndustrialOxadiazolesantifungal agentsmappicinesmechanismRhizoctonia solaniRice sheath blight

Identifiers

PMID42141780
PMCPMC13453227

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.