Evidence map›Paper›PMID 42141771›Full record

ArticleMediators of inflammation2026

Cytokine and Oxylipin Production in Resting and LPS-Stimulated Monocytes From Americans of African Ancestry Are Influenced by ALOX5 Promoter Tandem Repeat Polymorphisms.

Ryan G Snodgrass, Charles B Stephensen, Patrice Armstrong, Hooman Allayee, Isabel F Snodgrass, Kevin D Laugero, John W Newman

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Mediators of inflammation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ryan G SnodgrassDiet, Microbiome, and Immunity Research Unit, United States Department of Agriculture-Agricultural Research Services-Western Human Nutrition Research Center, Davis, California, USA, usda.gov.ORCID https://orcid.org/0000-0001-9896-5297
Charles B StephensenDiet, Microbiome, and Immunity Research Unit, United States Department of Agriculture-Agricultural Research Services-Western Human Nutrition Research Center, Davis, California, USA, usda.gov.
Patrice ArmstrongDepartment of Nutrition, University of California Davis, Davis, California, USA, ucdavis.edu.
Hooman AllayeeDepartment of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, USA, ucla.edu.
Isabel F SnodgrassWest Coast Metabolomics Center, Genome Center, University of California Davis, Davis, California, USA, ucdavis.edu.
Kevin D LaugeroDepartment of Nutrition, University of California Davis, Davis, California, USA, ucdavis.edu.
John W NewmanDepartment of Nutrition, University of California Davis, Davis, California, USA, ucdavis.edu.

Funding

NIH HHS AT003411NIH HHS HL079353US Department of Agriculture (USDA) - Agricultural Research Service (ARS) 2032-10700-002-00DUS Department of Agriculture (USDA) - Agricultural Research Service (ARS) 2032-10700-003-00D
6 · The paper itself

Abstract

The arachidonate 5-lipoxygenase (ALOX5) specificity protein 1 (Sp1) promoter tandem repeat polymorphism is associated with enhanced cardiovascular disease (CVD) risk. However, a functional understanding of these variants in immune cells central to disease development remains limited. We investigated oxylipin and cytokine production in resting and lipopolysaccharide (LPS)-stimulated CD14+ monocytes from individuals carrying promoter variants and common alleles of ALOX5. Compared to monocytes from subjects carrying two common five-repeat alleles (55 genotype), resting monocytes from individuals carrying one or more ALOX5 deletion (d) alleles (d5 and dd genotypes) produced increased levels of IL-1β, IL-6, TNF-ɑ, and IL-10 but lower quantities of putative trihydroxyeicosapenataenoic acid (TriHEPE) isomers detected with the same mass transition as resolvin E1 (RvE1) but slightly longer retention times. With the common 55 genotype, TriHEPEs increased as IL-6, IL-10, and TNF-ɑ production increased. This positive relationship between TriHEPEs and cytokines was diminished in monocytes with truncated ALOX5 alleles. In response to LPS, monocytes from individuals with d5 and dd genotypes produced higher levels of IL-1β, IL-6, and TNF-ɑ but not IL-10, as well as increased quantities of cyclooxygenase (COX) products 11-hydroxyeicosatetraenoic acid (11-HETE), prostaglandin E2 (PGE

Indexed as

Arachidonate 5-LipoxygenaseCytokinesLipopolysaccharidesMonocytesOxylipinsAdultBlack or African AmericanFemaleGenotypeHumansInterleukin-10Interleukin-1betaInterleukin-6MalePolymorphism, GeneticPromoter Regions, GeneticALOX5 protein, humanArachidonate 5-LipoxygenaseCytokinesInterleukin-10Interleukin-1betaInterleukin-6LipopolysaccharidesOxylipinsTumor Necrosis Factor-alpha5-LOXALOX5COXcyclooxygenasecytokinemonocyteoxylipin

Identifiers

PMID42141771
PMCPMC13179450

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.