ArticleAmerican journal of physiology. Heart and circulatory physiology2026
Modes of onset of ventricular arrhythmias in J-wave syndromes: mechanistic insights from computational modeling.
Article in American journal of physiology. Heart and circulatory physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Different modes of onset of ventricular arrhythmias (VA), preceded by characteristic electrocardiogram patterns, have been observed in patients with J-wave syndromes (JWS), including Brugada syndrome, early repolarization syndrome, and idiopathic ventricular fibrillation. However, the underlying mechanisms remain unclear. The goal of this study is to use computational modeling to elucidate the mechanisms for spontaneous initiation of VA in JWS, particularly the characteristic modes of onset shown in clinical settings. Phase-2 reentry (P2R) was induced by transient outward potassium currents (
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