ArticleBMC chemistry2026
Viscometric and UV-Visible spectroscopic characterization of L-Ascorbic Acid and Caffeine mixtures: insights into solute-solute and solute-solvent interactions.
Article in BMC chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study equips significant molecular intuition into the compatibility of L-Ascorbic Acid (LAA, solute) and caffeine (CAF, co-solute), two bio-actives widely co-formulated in nutraceutical and pharmaceutical products. Varying concentrations of LAA (0.02-0.14 [Formula: see text]) and CAF (0.025, 0.050, 0.075 [Formula: see text]) in aqueous medium are used in this present study. A cohesive approach combining viscometric measurements, thermodynamic analysis and UV-Visible spectroscopic analysis was employed to elucidate their intermolecular interactions in aqueous medium at varying working temperatures (293.15 K-313.15 K) and at atmospheric pressure. Dynamic viscosity data were scrutinized through the Jone-Dole equation to assess solute-solute and solute-solvent interactions, while transfer parameters, solvation numbers and thermodynamic functions were employed to explain hydration behaviour and viscous flow. Positive Jones-Dole coefficient [Formula: see text] and solvation number above 2.5 confirm predominant ion-solvent interactions and enhanced hydration structuring. Uprising trend of viscosity with solution concentration and downward slope of temperature derivative of [Formula: see text] [Formula: see text] indicate strengthened molecular associations across all systems. Thermodynamic parameters reveal higher activation free energies and contrasting enthalpies signatures for LAA-CAF systems, reflecting different molecular reorganization patterns. UV-Visible spectra exhibit hypsochromic, hyperchromic, hypochromic and bathochromic shifts upon mixing validating hydrogen bonding and dipole-dipole interactions. Collectively, these findings significantly deepen the molecular-level understanding of LAA-CAF compatibility and support the rational design of more stable, synergistic multi-component formulations.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.