Trial reportBMC oral health2026
Injectable platelet-rich fibrin (iPRF) and postoperative outcomes in mandibular impacted third molar surgery: a split-mouth randomized controlled trial.
Trial report in BMC oral health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07257328 (Comparison of Injectable Platelet-Rich Fibrin), which is not on this map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comparison of Injectable Platelet-Rich Fibrin (i-PRF) Application and Routine Surgical Extraction on Socket Healing Using a Split-Mouth Technique.
Who cites it
0 citing papers in PubMed.
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo compare phase-specific soft tissue healing (STH) and periodontal changes after mandibular impacted third molar (MITM) extraction with and without iPRF. MATERIALS AND
methodsThis single-blind, single-center, split-mouth, randomized controlled trial included patients with bilateral MITMs. Extraction sites were randomly assigned using simple randomization to either the iPRF group (test; irrigation with iPRF) or the control group (irrigation with saline). The primary outcome was STH, using Inflammatory Proliferative Remodeling (IPR) scale on days 3 and 14 and at week 6. Secondary outcomes included complete wound epithelialization (CWE), (days 7 and 14); postoperative average pain (PAP) during the first 3 days; and periodontal parameters-gingival recession (GR), probing pocket depth (PPD), and clinical attachment level (CAL)- measured at baseline and 6 weeks at the distal aspect of the second molar.
resultsA total of 32 patients (mean age: 25.09 ± 5.16 years) were included. iPRF group showed significantly higher STH scores in the inflammatory and proliferative phases and lower PAP. No significant intergroup differences were observed in CWE. Both groups showed significant reductions in PPD and significant increases in GR at 6 weeks, while CAL improved significantly only in iPRF group. Intergroup comparisons revealed significantly higher baseline PPD and CAL values in iPRF group; however, no differences were observed between groups at 6 weeks. Change analysis demonstrated a significantly greater CAL gain in iPRF group.
conclusionThe application of iPRF appears to enhance early STH, reduce PAP, and promote favorable changes in CAL following MITM extraction.
trial registrationNCT07257328, registered retrospectively on November 20, 2025.
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