Evidence map›Paper›PMID 42141378›Full record

ArticleJournal of veterinary pharmacology and therapeutics2026

Plasma Pharmacokinetic Profile of Fipronil 1% Pour-On in Cattle: Photodegradation and the Sustained Systemic Persistence of Fipronil Sulfone.

Stefani Maria Ferreira, Leonila Ester Reinert Raspantini, Giselle Kindlein, Fabiano Barreto, Caroline Andrade Tomaszewski, Tamara Dos Santos Castilhos, Daniel Rodrigo Hillesheim, Silvana Lima Górniak, André Tadeu Gotardo

Abstract read
In one paragraph

Article in Journal of veterinary pharmacology and therapeutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Stefani Maria FerreiraResearch Centre for Veterinary Toxicology (CEPTOX), Department of Pathology, School of Veterinary Medicine and Animal Sciences, University of São Paulo, Pirassununga, SP, Brazil.ORCID https://orcid.org/0009-0000-0841-3182
Leonila Ester Reinert RaspantiniResearch Centre for Veterinary Toxicology (CEPTOX), Department of Pathology, School of Veterinary Medicine and Animal Sciences, University of São Paulo, Pirassununga, SP, Brazil.ORCID https://orcid.org/0000-0003-4257-5315
Giselle KindleinMinistry of Agriculture and Livestock, Esplanada dos Ministérios, Brasília, DF, Brazil.ORCID https://orcid.org/0009-0000-7227-7875
Fabiano BarretoFederal Agricultural Defense Laboratory (LFDA-RS), Ministry of Agriculture and Livestock, Porto Alegre, RS, Brazil.ORCID https://orcid.org/0000-0003-4259-4583
Caroline Andrade TomaszewskiFederal Agricultural Defense Laboratory (LFDA-RS), Ministry of Agriculture and Livestock, Porto Alegre, RS, Brazil.ORCID https://orcid.org/0000-0002-2202-8843
Tamara Dos Santos CastilhosFederal Agricultural Defense Laboratory (LFDA-RS), Ministry of Agriculture and Livestock, Porto Alegre, RS, Brazil.
Daniel Rodrigo HillesheimFederal Agricultural Defense Laboratory (LFDA-RS), Ministry of Agriculture and Livestock, Porto Alegre, RS, Brazil.
Silvana Lima GórniakResearch Centre for Veterinary Toxicology (CEPTOX), Department of Pathology, School of Veterinary Medicine and Animal Sciences, University of São Paulo, Pirassununga, SP, Brazil.ORCID https://orcid.org/0000-0002-2766-8751
André Tadeu GotardoResearch Centre for Veterinary Toxicology (CEPTOX), Department of Pathology, School of Veterinary Medicine and Animal Sciences, University of São Paulo, Pirassununga, SP, Brazil.ORCID https://orcid.org/0000-0001-7297-0522

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 404032/2023-0
6 · The paper itself

Abstract

This study characterized the long-term pharmacokinetic profile of a 1% fipronil pour-on formulation in Nellore bulls under field conditions. Seventeen animals received a single topical dose (1 mg/kg), and plasma concentrations of fipronil and its metabolites (sulfone and desulfinyl) were monitored for 175 days using LC-MS/MS. Fipronil was rapidly absorbed, reaching a maximum concentration C

Indexed as

InsecticidesPyrazolesAnimalsArea Under CurveCattleHalf-LifeMalePhotolysisfipronilfipronil sulfoneInsecticidesPyrazolesBos indicusfipronil desulfinylmarker residuephenylpyrazolesafety assessments

Identifiers

PMID42141378
PMCPMC13552523

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.