Evidence map›Paper›PMID 42141306›Full record

ArticleNature neuroscience2026

Excitatory synapses onto axonic spines jump-start action potentials and route information flow.

Hongkun Yang, Kun Wang, Yijie Chen, Wei Ke, Liang Li, Yilin Tai, Shuyang Wang, Yu Kong, Xu Wang, Wenxin Zhang and 7 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Hongkun YangDepartment of Neurology, Huashan Hospital, Institute for Translational Brain Research, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, MOE Innovative Center for New Drug Development of Immune Inflammatory Diseases, Fudan University, Shanghai, China.
Kun WangDepartment of Neurology, Huashan Hospital, Institute for Translational Brain Research, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, MOE Innovative Center for New Drug Development of Immune Inflammatory Diseases, Fudan University, Shanghai, China.
Yijie ChenSchool of Life Sciences, Nanjing University, Nanjing, China.
Wei KeDepartment of Neurology, Huashan Hospital, Institute for Translational Brain Research, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, MOE Innovative Center for New Drug Development of Immune Inflammatory Diseases, Fudan University, Shanghai, China.
Liang LiDepartment of Neurology, Huashan Hospital, Institute for Translational Brain Research, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, MOE Innovative Center for New Drug Development of Immune Inflammatory Diseases, Fudan University, Shanghai, China.
Yilin TaiDepartment of Neurology, Huashan Hospital, Institute for Translational Brain Research, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, MOE Innovative Center for New Drug Development of Immune Inflammatory Diseases, Fudan University, Shanghai, China.ORCID http://orcid.org/0009-0005-7440-0263
Shuyang WangDepartment of Neurology, Zhongshan Hospital, Fudan University, Shanghai, China.
Yu KongCenter for Excellence in Brain Science and Technology (Institute of Neuroscience), Chinese Academy of Science, Shanghai, China.
Xu WangCenter for Excellence in Brain Science and Technology (Institute of Neuroscience), Chinese Academy of Science, Shanghai, China.
Wenxin ZhangDepartment of Neurology, Huashan Hospital, Institute for Translational Brain Research, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, MOE Innovative Center for New Drug Development of Immune Inflammatory Diseases, Fudan University, Shanghai, China.ORCID http://orcid.org/0009-0007-7547-6352
Bo LiDepartment of Neurology, Huashan Hospital, Institute for Translational Brain Research, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, MOE Innovative Center for New Drug Development of Immune Inflammatory Diseases, Fudan University, Shanghai, China.ORCID http://orcid.org/0000-0003-1492-0919
Yong ZhangNeuroscience Research Institute and Department of Neurobiology, School of Basic Medical Sciences, Peking University, Beijing, China.ORCID http://orcid.org/0000-0001-8765-7037
Miao HeDepartment of Neurology, Huashan Hospital, Institute for Translational Brain Research, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, MOE Innovative Center for New Drug Development of Immune Inflammatory Diseases, Fudan University, Shanghai, China.ORCID http://orcid.org/0000-0003-0731-6801
Chao TanDepartment of Neurology, Huashan Hospital, Institute for Translational Brain Research, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, MOE Innovative Center for New Drug Development of Immune Inflammatory Diseases, Fudan University, Shanghai, China.
Jintai YuDepartment of Neurology, Huashan Hospital, Institute for Translational Brain Research, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, MOE Innovative Center for New Drug Development of Immune Inflammatory Diseases, Fudan University, Shanghai, China.ORCID http://orcid.org/0000-0002-2532-383X
Jian WangDepartment of Neurology, Huashan Hospital, Institute for Translational Brain Research, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, MOE Innovative Center for New Drug Development of Immune Inflammatory Diseases, Fudan University, Shanghai, China.ORCID http://orcid.org/0000-0002-2748-395X
Yousheng ShuDepartment of Neurology, Huashan Hospital, Institute for Translational Brain Research, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, MOE Innovative Center for New Drug Development of Immune Inflammatory Diseases, Fudan University, Shanghai, China. yousheng@fudan.edu.cn.ORCID http://orcid.org/0000-0002-2834-2876

Funding

National Natural Science Foundation of China (National Science Foundation of China) 32130044National Natural Science Foundation of China (National Science Foundation of China) 32200953National Natural Science Foundation of China (National Science Foundation of China) T2241002
6 · The paper itself

Abstract

Synaptic inputs onto the dendrites and cell body integrate and trigger action potentials (APs) at the axon initial segment (AIS). The AIS receives GABAergic synaptic inputs; however, the structure and function of glutamatergic synapses at the AIS remain poorly understood. Here, we show that, in adult mice, the AIS exhibits axonic spines in about half of the neurons examined in three brain regions: the dorsal lateral septum (dLS), bed nucleus of the stria terminalis and striatum. In the dLS, axonic spines express ionotropic glutamate receptors and undergo structural plasticity. Voltage-gated Na

Indexed as

Action PotentialsAxonsDendritic SpinesExcitatory Postsynaptic PotentialsNeuronsSynapsesAnimalsHippocampusMiceMice, Inbred C57BLMice, TransgenicPatch-Clamp Techniques

Identifiers

PMID42141306

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.