Evidence map›Paper›PMID 42141262›Full record

ArticleInnere Medizin (Heidelberg, Germany)2026

[Infection with Orientia tsutsugamushi and hospital-acquired pneumonia].

Ilka Grewe, Saskia Winzer, Silja Steinmann, Paul Francke, Aiman Gamal Abdelrahim, Annette Hennigs, Marylyn M Addo, Michael Ramharter, Dominic Wichmann, Stefan Schmiedel

Abstract readCase ReportsEnglish Abstract
In one paragraph

Article in Innere Medizin (Heidelberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ilka GreweFirst Department of Medicine, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20251, Hamburg, Deutschland. i.grewe@uke.de.
Saskia WinzerInstitute for Infection Research and Vaccine Development (IIRVD), Center for Internal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Deutschland.
Silja SteinmannFirst Department of Medicine, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20251, Hamburg, Deutschland.
Paul FranckeDivision of Respiratory Medicine, Second Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Deutschland.
Aiman Gamal AbdelrahimFirst Department of Medicine, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20251, Hamburg, Deutschland.
Annette HennigsFirst Department of Medicine, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20251, Hamburg, Deutschland.
Marylyn M AddoFirst Department of Medicine, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20251, Hamburg, Deutschland.
Michael RamharterFirst Department of Medicine, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20251, Hamburg, Deutschland.
Dominic WichmannDepartment of Intensive Care Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Deutschland.
Stefan SchmiedelFirst Department of Medicine, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20251, Hamburg, Deutschland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTsutsugamushi fever is an infection caused by Orientia tsutsugamushi that is rarely diagnosed in Europe but endemic in several Asian countries and in Chile. Its clinical presentation is often nonspecific, ranging from fever, myalgia, lymphadenopathy, and a maculopapular rash to severe disease with multiorgan involvement. CASE REPORT: A 34-year-old man presented with fever, myalgia, lymphadenopathy, and a maculopapular rash after returning from Thailand. Despite empiric antimicrobial therapy, his condition deteriorated rapidly, with respiratory failure, decreased vigilance, and hypotension. PCR testing from peripheral blood confirmed Orientia tsutsugamushi. Treatment with doxycycline, along with meropenem for hospital-acquired pneumonia, resulted in rapid clinical improvement.

conclusionsThis case highlights the importance of considering tsutsugamushi fever in febrile travellers returning from endemic regions. Early presumptive or PCR-based diagnostics and initiation of effective therapy are crucial to prevent severe disease with multiorgan involvement and secondary complications.

Indexed as

Healthcare-Associated PneumoniaOrientia tsutsugamushiScrub TyphusAdultAnti-Bacterial AgentsDiagnosis, DifferentialDoxycyclineFever of Unknown OriginHumansMaleMeropenemThailandTravelAnti-Bacterial AgentsDoxycyclineMeropenemExanthemaFever of unknown originRickettsia infectionsScrub typhusTsutsugamushi-fever

Identifiers

PMID42141262
PMCPMC13395899

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.