Evidence map›Paper›PMID 42141252›Full record

ArticlePrenatal diagnosis2026

Impact of Fetoscopic Surgery on the Myometrium: Experimental Study in an Ovine Model of Myelomeningocele.

Enora Parc, Eugénie Jolivet, Corentin Maillet, Yoann Athiel, Jean-Marie Jouannic, Lucie Guilbaud

Abstract read
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In one paragraph

Article in Prenatal diagnosis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Enora ParcDepartment of Fetal Medicine, Sorbonne University, AP-HP, Armand Trousseau Hospital, DMU ORIGYNE, National Reference Center for Rare Diseases: Spin@, Paris, France.
Eugénie JolivetDepartment of Fetal Medicine, Sorbonne University, AP-HP, Armand Trousseau Hospital, DMU ORIGYNE, National Reference Center for Rare Diseases: Spin@, Paris, France.
Corentin MailletDepartment of Fetal Medicine, Sorbonne University, AP-HP, Armand Trousseau Hospital, DMU ORIGYNE, National Reference Center for Rare Diseases: Spin@, Paris, France.
Yoann AthielDepartment of Fetal Medicine, Sorbonne University, AP-HP, Armand Trousseau Hospital, DMU ORIGYNE, National Reference Center for Rare Diseases: Spin@, Paris, France.ORCID https://orcid.org/0000-0003-2665-8292
Jean-Marie JouannicDepartment of Fetal Medicine, Sorbonne University, AP-HP, Armand Trousseau Hospital, DMU ORIGYNE, National Reference Center for Rare Diseases: Spin@, Paris, France.
Lucie GuilbaudDepartment of Fetal Medicine, Sorbonne University, AP-HP, Armand Trousseau Hospital, DMU ORIGYNE, National Reference Center for Rare Diseases: Spin@, Paris, France.

Funding

Agence de la Biomédecine 23AMP002Fondation de l'Avenir pour la Recherche Médicale Appliquée AP-RM-23-019Sorbonne Université
6 · The paper itself

Abstract

objectiveTo investigate uterine healing at delivery after fetoscopic myelomeningocele (MMC) closure in an ovine model.

methodsThis descriptive study was conducted in Romane ewes. Fetal MMC lesions were created after hysterotomy at 75 days of gestation. Fetoscopic MMC closure using three trocars was performed at 90 days of gestation and cesarean delivery at 143 days. Subtotal hysterectomy was performed, and each hysterectomy specimen was examined in fresh condition. The areas of interest and the surrounding intact tissue were then sampled en bloc and fixed in 4% buffered formaldehyde solution for 3-6 weeks. Macroscopic appearance of the scars was assessed in fresh condition. Microscopic examinations were conducted in fixed samples.

resultsThe uteri of six ewes were studied. Macroscopic examination revealed identifiable fetoscopic scars without any scar dehiscence. There was no evidence of a difference in thickness between scarred and healthy adjacent myometrium, although a slightly lower proportion of muscle fibers was observed in scarred areas.

conclusionsOur study demonstrates that myometrial healing of trocar orifices is complete 53 days after fetoscopic MMC closure in an ovine model. Given the limitations of an ovine model, further studies are needed to determine the risk of uterine rupture and the optimal obstetric management of patients after fetoscopic MMC closure.

Indexed as

FetoscopyMeningomyeloceleMyometriumAnimalsCicatrixDisease Models, AnimalFemalePregnancySheepWound Healingfetal surgeryfetoscopyMMC closuremyelomeningoceleovine modeluterine healing

Identifiers

PMID42141252
PMCPMC13377257

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.