Evidence map›Paper›PMID 42141214›Full record

ReviewNature reviews. Clinical oncology2026

Transforming perioperative treatment of gastro-oesophageal adenocarcinoma: triumphs, setbacks and future horizons.

Hongcheng Zhu, Florian Lordick, Yelena Y Janjigian, Sun Young Rha, Magnus Nilsson, Kohei Shitara, Richard Owen, Zhen Zhang, Elizabeth C Smyth

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Clinical oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hongcheng ZhuDepartment of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, China.
Florian LordickDepartment of Medicine and University Cancer Center Leipzig, University of Leipzig Medical Center, Leipzig, Germany.ORCID http://orcid.org/0000-0001-8591-9339
Yelena Y JanjigianGastrointestinal Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Sun Young RhaDivision of Medical Oncology, Yonsei Cancer Center, Yonsei University Health System, Seoul, South Korea.
Magnus NilssonDivision of Surgery and Oncology, Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet, Stockholm, Sweden.
Kohei ShitaraDepartment of Gastrointestinal Oncology, National Cancer Center Hospital East, Kashiwa City, Japan.ORCID http://orcid.org/0000-0001-5196-3630
Richard OwenNuffield Department of Surgical Sciences, University of Oxford, Oxford, UK.
Zhen ZhangDepartment of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, China. zhen_zhang@fudan.edu.cn.
Elizabeth C SmythOxford NIHR Biomedical Research Centre, Churchill Hospital, Oxford, UK. elizabeth.smyth2@nhs.net.ORCID http://orcid.org/0000-0002-4667-1817

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The landscape of gastro-oesophageal adenocarcinoma (GEA) management has undergone substantial transformation over the past decade owing to shifts in epidemiology, evolving treatment paradigms and the integration of new therapeutic strategies. The global burden of GEA continues to rise, with differing patterns observed in Asia compared with Western countries. Important insights gleaned from recent high-profile clinical trials - both successful and negative - have considerably reshaped perioperative treatment strategies, redefining the roles of chemotherapy, radiotherapy, immune checkpoint inhibitors and targeted therapies. Although still investigational, organ-preserving approaches and circulating tumour DNA (ctDNA)-based patient stratification are shaping the direction of future GEA management. By consolidating these developments, this Review aims to provide clinicians and researchers with a comprehensive and structured guide to the state-of-the-art perioperative management of GEA, emphasizing the underlying biology, clinical implications and future directions.

Indexed as

AdenocarcinomaEsophageal NeoplasmsPerioperative CareStomach NeoplasmsHumans

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.