ArticleNature cancer2026
CD300ld on pathologically activated neutrophils promotes tumor immune suppression by binding phosphatidylserine on CD8
Abstract read
In one paragraph
Article in Nature cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Neutrophil-driven immunosuppression in cancer.Cell insight · 2026Review
- Golgi pH buffers ferroptosis sensitivity.Nature cancer · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors.
Chaoxiong Wang *Key Laboratory of Multi-Cell Systems, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.ORCID http://orcid.org/0000-0003-3403-7074
Peixuan Zheng *Key Laboratory of Multi-Cell Systems, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.ORCID http://orcid.org/0000-0003-3963-3051
Anhui Wang *Interdisciplinary Research Center for Biology and Chemistry, Liaoning Normal University, Dalian, China.
Xinrui Fan *Key Laboratory of Multi-Cell Systems, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.ORCID http://orcid.org/0009-0002-2933-0460
Tianxiang Li *Key Laboratory of Multi-Cell Systems, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.
Jingjing HongKey Laboratory of Multi-Cell Systems, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.
Runze WangKey Laboratory of Multi-Cell Systems, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.
Chunyan ZhangKey Laboratory of Multi-Cell Systems, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.
Chaogui LuoKey Laboratory of Multi-Cell Systems, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.ORCID http://orcid.org/0009-0006-4983-3275
Weiwei YangKey Laboratory of Multi-Cell Systems, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.
Dong GaoKey Laboratory of Multi-Cell Systems, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.ORCID http://orcid.org/0000-0003-1821-2741
Adili SalaiSecond Department of Thoracic Surgery, Tumor Hospital Affiliated to Xinjiang Medical University, Wulumuqi, China.
Min LuoInstitute of Pediatrics of Children's Hospital of Fudan University, the Shanghai Key Laboratory of Medical Epigenetics, the International Co-laboratory of Medical Epigenetics and Metabolism, Ministry of Science and Technology, Institutes of Biomedical Sciences, Fudan University, Shanghai, China.ORCID http://orcid.org/0000-0001-5732-4848
Zhigang LuInstitute of Pediatrics of Children's Hospital of Fudan University, the Shanghai Key Laboratory of Medical Epigenetics, the International Co-laboratory of Medical Epigenetics and Metabolism, Ministry of Science and Technology, Institutes of Biomedical Sciences, Fudan University, Shanghai, China.ORCID http://orcid.org/0000-0002-2880-7848
Dianfan LiSchool of Agriculture and Biotechnology, Sun Yat-Sen University, Shenzhen, China. lidf9@mail.sysu.edu.cn.ORCID http://orcid.org/0000-0003-4729-4678
Moubin LinCenter for Clinical Research and Translational Medicine, Yangpu Hospital, Tongji University School of Medicine, Shanghai, China. lmbin@hotmail.com.ORCID http://orcid.org/0000-0002-0686-688X
Jiayin PengKey Laboratory of Multi-Cell Systems, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China. jiayin.peng@sibcb.ac.cn.ORCID http://orcid.org/0000-0002-0356-574X
Guohui LiInterdisciplinary Research Center for Biology and Chemistry, Liaoning Normal University, Dalian, China. ghli@dicp.ac.cn.ORCID http://orcid.org/0000-0001-8223-705X
Shuo HanKey Laboratory of Multi-Cell Systems, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China. shuohan@sibcb.ac.cn.ORCID http://orcid.org/0009-0007-9788-2087
Yun ZhaoKey Laboratory of Multi-Cell Systems, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China. yunzhao@sibcb.ac.cn.ORCID http://orcid.org/0000-0002-7807-6094
Funding
National Natural Science Foundation of China (National Science Foundation of China) 22203089National Natural Science Foundation of China (National Science Foundation of China) 22377126National Natural Science Foundation of China (National Science Foundation of China) 22573043National Natural Science Foundation of China (National Science Foundation of China) 32130024National Natural Science Foundation of China (National Science Foundation of China) 32400757National Natural Science Foundation of China (National Science Foundation of China) 32521007National Natural Science Foundation of China (National Science Foundation of China) 92368102
Abstract
The immunosuppressive tumor microenvironment remains a major obstacle to successful immunotherapy. Pathologically activated neutrophils, alternatively termed polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs), drive tumor immune evasion primarily by inducing CD8
Indexed as
CD8-Positive T-LymphocytesNeutrophilsPhosphatidylserinesReceptors, ImmunologicTumor EscapeAnimalsFemaleHumansMiceMice, Inbred C57BLNeutrophil ActivationTumor MicroenvironmentPhosphatidylserinesReceptors, Immunologic
Identifiers
PMID
42141174What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.