ReviewNature cell biology2026
Mechanisms and functions of large extracellular vesicle biogenesis.
Review in Nature cell biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- A novel imaging-based approach for large extracellular vesicle detection and prognostic stratification in metastatic breast cancer.The journal of liquid biopsy · 2026Article
- The recent progression of extracellular vesicles application in osteoporosis.Frontiers in pharmacology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Owing to the ability of extracellular vesicles (EVs) to encapsulate and transfer biomolecules for intercellular communication, EVs are recognized as promising candidates as biomarkers and therapeutic delivery vehicles. Small EVs (S-EVs), below 200 nm in diameter, have previously been the major focus in the EV field, but large EVs (L-EVs) are gaining considerable interest, with many distinct subsets of L-EVs having been described in the past few years. Here we review L-EV biogenesis from a context-specific perspective, focusing on the biological settings that drive L-EV formation. We also discuss the roles of L-EVs in facilitating the removal of unwanted cellular content and intercellular communication. Finally, we identify key challenges in the L-EV field and discuss future investigations towards harnessing L-EVs for diagnostic and therapeutic applications.
Indexed as
Identifiers
42141161What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.