Evidence map›Paper›PMID 42140935›Full record

ArticleNature communications2026

Visualization of the complete preprimosome reveals the structural mechanisms governing DNA replication restart.

Peter L Ducos, Alexander T Duckworth, Kenneth A Satyshur, James L Keck, Timothy Grant

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Peter L Ducos *John and Jeanne Rowe Center for Research in Virology, Morgridge Institute for Research, Madison, WI, USA.
Alexander T Duckworth *John and Jeanne Rowe Center for Research in Virology, Morgridge Institute for Research, Madison, WI, USA.ORCID http://orcid.org/0000-0002-7713-4117
Kenneth A SatyshurDepartment of Biomolecular Chemistry, University of Wisconsin-Madison, Madison, WI, USA.ORCID http://orcid.org/0000-0001-9371-2493
James L KeckDepartment of Biomolecular Chemistry, University of Wisconsin-Madison, Madison, WI, USA. jlkeck@wisc.edu.ORCID http://orcid.org/0000-0002-5961-0220
Timothy GrantJohn and Jeanne Rowe Center for Research in Virology, Morgridge Institute for Research, Madison, WI, USA. tim.grant@wisc.edu.ORCID http://orcid.org/0000-0002-4855-8703

Funding

Structure and Function of the Bacterial PrimosomeR01GM098885 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI James L Keck · 2012 to 2026
$4.0M
NIGMS NIH HHS R01 GM098885U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) RO1GM098885.
6 · The paper itself

Abstract

Replication restart pathways reinitiate DNA replication processes following their premature termination. In Escherichia coli, this essential process begins with regulated assembly of the preprimosome complex, comprising the PriA, PriB, and DnaT proteins, onto an abandoned replication fork. Here, we present two distinct preprimosome structures. One represents an intermediate stage in preprimosome assembly with a single DnaT C-terminal domain (DnaT

Indexed as

DNA, BacterialDNA-Binding ProteinsDNA ReplicationEscherichia coliEscherichia coli ProteinsDNA HelicasesDNA, Single-StrandedProtein BindingProtein DomainsDNA, BacterialDNA-Binding ProteinsDNA HelicasesDNA, Single-StrandedDnaT protein, E coliEscherichia coli ProteinspriA protein, E coliPriB protein, E coli

Identifiers

PMID42140935
PMCPMC13377028

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.