Evidence map›Paper›PMID 42140830›Full record

ArticleUltrasound in medicine & biology2026

Longitudinal Assessment of Quantitative Metrics for Skeletal Muscle Health Using 3D Rotational Shear Wave Elasticity Imaging in the Vastus Lateralis.

Shruthi Srinivasan, Wren E Wightman, Kaden D Bock, David P Bradway, Ned C Rouze, Mark L Palmeri, Lisa D Hobson-Webb, Kathryn R Nightingale

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In one paragraph

Article in Ultrasound in medicine & biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Shruthi SrinivasanDepartment of Biomedical Engineering, Duke University, Durham, NC, USA. Electronic address: shruthi.srinivasan@duke.edu.
Wren E WightmanDepartment of Biomedical Engineering, Duke University, Durham, NC, USA.
Kaden D BockDepartment of Biomedical Engineering, Duke University, Durham, NC, USA.
David P BradwayDepartment of Biomedical Engineering, Duke University, Durham, NC, USA.
Ned C RouzeDepartment of Biomedical Engineering, Duke University, Durham, NC, USA.
Mark L PalmeriDepartment of Biomedical Engineering, Duke University, Durham, NC, USA.
Lisa D Hobson-WebbDepartment of Neurology, Duke University Health & School of Medicine, Durham, NC, USA.
Kathryn R NightingaleDepartment of Biomedical Engineering, Duke University, Durham, NC, USA.

Funding

3D Shearwave Elasticity Biomarker Development for Neuromuscular DiseaseR01EB033064 · NIBIB · DUKE UNIVERSITY · PI NIGHTINGALE, KATHRYN RADABAUGH · 2022 to 2025
$2.3M
NIBIB NIH HHS R01 EB033064
6 · The paper itself

Abstract

objectiveUltrasonic 3D rotational shear wave elasticity imaging (3D-RSWEI) has previously been used to quantify the mechanical properties of muscle with good precision in single timepoint studies. However, to date, the longitudinal variability of these measurements has not been evaluated. Herein, we report the longitudinal measurements of muscle stiffness and anisotropy assessed using 3D-RSWEI over a 3 month period.

methods3D-RSWEI measurements were made in vivo in the healthy vastus lateralis of 10 participants. Over 3 mo, we quantified the shear wave speed (SWS) along and across the fibers, along with fractional anisotropy (FA) at multiple knee flexion angles (≤45

resultsThroughout the duration of the study and across all participants, SWS measurements were consistent to within 10%CoV, with FA measurements consistent to within 13%. Fitting SWS growth versus knee flexion yielded a β

conclusionThe low variability of these SWEI-based metrics over 3 months in healthy volunteers provides a reference for designing longitudinal studies to evaluate their sensitivity to histopathologic changes associated with muscle disease progression.

Indexed as

Elasticity Imaging TechniquesImaging, Three-DimensionalQuadriceps MuscleAdultAnisotropyFemaleHumansLongitudinal StudiesMaleReproducibility of ResultsYoung AdultAnisotropyKnee flexionLongitudinal measurementsShear wave elasticity imagingShear wave speedVastus lateralis

Identifiers

PMID42140830
PMCPMC13340268

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.