Evidence map›Paper›PMID 42140673›Full record

ArticleGenes & development2026

CDK1 and CEP97 cooperatively control centriole length to orchestrate ciliogenesis and developmental patterning.

Yue Liu, Zhengmao Wang, Tanvi Sinha, Kathy H Li, Robert J Chalkley, Vicente Herranz-Pérez, Chang Xie, Bradley K Yoder, Alma L Burlingame, Brian L Black and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes & development, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yue LiuDepartment of Biochemistry and Biophysics, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, California 94158, USA.ORCID 0000-0001-9877-6138
Zhengmao WangDepartment of Biochemistry and Biophysics, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, California 94158, USA.
Tanvi SinhaDepartment of Biochemistry and Biophysics, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, California 94158, USA.
Kathy H LiDepartment of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, California 94158, USA.
Robert J ChalkleyDepartment of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, California 94158, USA.
Vicente Herranz-PérezLaboratory of Comparative Neurobiology, Institute Cavanilles, University of Valencia, Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED)-Carlos III Health Institute (ISCIII), Paterna 46980, Spain.
Chang XieDepartment of Biochemistry and Biophysics, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, California 94158, USA.
Bradley K YoderDepartment of Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA.
Alma L BurlingameDepartment of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, California 94158, USA.
Brian L BlackDepartment of Biochemistry and Biophysics, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, California 94158, USA.
Jeremy F ReiterDepartment of Biochemistry and Biophysics, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, California 94158, USA; jeremy.reiter@ucsf.edu.ORCID 0000-0002-6512-320X

Funding

Hedgehog signaling at the cell's antenna: Smoothened and the primary ciliumR01AR054396 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Jeremy F Reiter · 2007 to 2026
$9.0M
Understanding Ciliary Functions in Mammalian DevelopmentR01HD089918 · NICHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI REITER, JEREMY F, YODER, BRADLEY K. · 2017 to 2021
$3.0M
Generation and analysis of mouse models to define the roles of the ALS-associated factor Zfp106/ZNF106 in neurodegenerationR01NS126499 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Brian L Black · 2024 to 2026
$1.2M
Transcriptional control of endocardial-specific gene expressionR01HL177462 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Brian L Black · 2025 to 2026
$1.1M
NHLBI NIH HHS R01 HL177462NIAMS NIH HHS R01 AR054396NICHD NIH HHS R01 HD089918NINDS NIH HHS R01 NS126499
6 · The paper itself

Abstract

Architecture is critical for organelle function. The lengths of centrioles, key components of centrosomes, are tightly regulated. We adapted centrosome purification approaches to measure centrosomal protein phosphorylation. Centrosome-specific phosphoproteomics with and without cyclin-dependent kinase 1 (CDK1) activity revealed that CDK1 phosphorylates many centriolar proteins involved in centriole length control, including Centrobin. CDK1 regulated centriole length synergistically with CEP97-CCP110, a local centriolar complex. CEP97 restricted Centrobin localization to centrioles, whereas CDK1-dependent phosphorylation suppressed Centrobin's ability to promote centriole elongation. Thus, CDK1 and CEP97-CCP110 both restrict centriole elongation by inhibiting the function of Centrobin, a centriole elongation factor, but via different mechanisms. Overelongated centrioles failed to support ciliogenesis in human cells and in mouse embryos. Removing CEP97 during mouse development caused centriole overelongation, impaired ciliogenesis and attenuated Hedgehog (HH) signaling, disrupting mouse heart development. We conclude that CEP97-CCP110 and CDK1 cooperatively restrict Centrobin function to control centriole length, critical for mammalian development.

Indexed as

CDC2 Protein KinaseCentriolesCentrosomal Associated ProteinsCiliaAnimalsCell Cycle ProteinsHedgehog ProteinsHumansMiceMicrotubule-Associated ProteinsPhosphoproteinsPhosphorylationSignal TransductionCCP110 protein, humanCDC2 Protein KinaseCell Cycle ProteinsCentrosomal Associated ProteinsCEP97 protein, humanHedgehog ProteinsMicrotubule-Associated ProteinsPhosphoproteinscell cyclecentrioleCentrobinCEP97cyclin-dependent kinase 1developmental patterningHedgehog signalingphosphoproteomicsphosphorylationprimary cilia

Identifiers

PMID42140673
PMCPMC13322075

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.