Evidence map›Paper›PMID 42140484›Full record

ArticleChest2026

Higher Respiratory Muscle Oxygen Cost of Breathing During Exercise in Heart Failure With Preserved Ejection Fraction.

Tarin C Phillips, Eric J Bruhn, Gizem Cifci, Barry A Borlaug, Thomas P Olson, Joshua R Smith

Abstract read
In one paragraph

Article in Chest, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Tarin C PhillipsDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN.
Eric J BruhnDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN.
Gizem CifciDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN.
Barry A BorlaugDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN.
Thomas P OlsonDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN.
Joshua R SmithDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN. Electronic address: smith.joshua1@mayo.edu.

Funding

Peripheral mechanisms of exercise intolerance in HFpEFR01HL175086 · NHLBI · MAYO CLINIC ROCHESTER · PI Joshua R. Smith · 2024 to 2026
$2.3M
Adding Inspiratory Muscle Training to Optimize Cardiac Rehabilitation for Heart FailureR01HL176491 · NHLBI · MAYO CLINIC ROCHESTER · PI Joshua R. Smith · 2025 to 2026
$1.5M
NHLBI NIH HHS R01 HL175086NHLBI NIH HHS R01 HL176491
6 · The paper itself

Abstract

backgroundPatients with heart failure with preserved ejection fraction (HFpEF) have pulmonary system abnormalities resulting in impaired ventilatory reserve and heightened respiratory muscle work during submaximal exercise. RESEARCH QUESTION: Do patients with HFpEF have higher respiratory muscle oxygen uptake (V˙o STUDY DESIGN AND

methodsPatients with HFpEF (n = 13) and control participants (n = 16) completed 2 visits. The first visit included pulmonary function tests and an incremental exercise test. On the second visit, participants mimicked their exercise breathing patterns across a range of work rates (voluntary hyperpnea) in the absence of exercise to quantify respiratory muscle V˙o

resultsDuring exercise at 40 W, patients with HFpEF had higher respiratory muscle V˙o

interpretationOur results show that respiratory muscle V˙o

Indexed as

ExerciseHeart FailureOxygen ConsumptionRespiratory MusclesStroke VolumeAgedExercise TestExercise ToleranceFemaleHumansMaleMiddle AgedRespiratory Function TestsdiaphragmHFpEFrespiratory mechanicsventilatory limitation

Identifiers

PMID42140484
PMCPMC13316718

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.