Evidence map›Paper›PMID 42140436›Full record

ArticleThe Journal of biological chemistry2026

Acid-sensing ion channel 2a assembles with epithelial Na

Shujie Shi, Sarah Christine M Whelan, Kennedy G Szekely, Ossama B Kashlan, Heather Drummond, Thomas R Kleyman

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Shujie ShiRenal-Electrolyte Division, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Sarah Christine M WhelanRenal-Electrolyte Division, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Kennedy G SzekelyRenal-Electrolyte Division, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Ossama B KashlanRenal-Electrolyte Division, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Heather DrummondPhysiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Thomas R KleymanRenal-Electrolyte Division, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; Department of Cell Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. Electronic address: kleyman@pitt.edu.

Funding

Resource Development CoreU54DK137329 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Thomas R Kleyman · 2023 to 2026
$4.8M
ENaC regulation and its role in blood pressure homeostasisR01HL147818 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Annet Kirabo, Thomas R Kleyman · 2019 to 2026
$4.6M
Degenerin and TrpC6 channels in renal vascular mechanosesnsor signaling and protection against injury.R01DK137167 · NIDDK · UNIVERSITY OF MISSISSIPPI MED CTR · PI Heather A Drummond, Thomas R Kleyman · 2024 to 2026
$1.8M
Role of PON3 in regulating renal Na+ and K+ homeostasisR01DK130901 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SHI, SHUJIE · 2021 to 2025
$1.6M
NHLBI NIH HHS R01 HL147818NIDDK NIH HHS R01 DK130901NIDDK NIH HHS R01 DK137167NIDDK NIH HHS U54 DK137329
6 · The paper itself

Abstract

ASIC2 and ENaC subunits are required for stretch-induced mechanoreceptor currents in renal vascular smooth muscle cells and pressure-induced constriction responses in small renal arteries and arterioles. To examine whether ENaC subunits and ASIC2 can form mechanosensitive ion channels, we co-expressed ASIC2a with ENaC β and γ subunits in Xenopus oocytes to test the channel's response to flow-induced shear stress by changing the perfusion rates with Na

Indexed as

Acid Sensing Ion ChannelsEpithelial Sodium ChannelsAmilorideAnimalsFemaleHumansMechanotransduction, CellularOocytesProtein SubunitsXenopus laevisAcid Sensing Ion ChannelsAmilorideEpithelial Sodium ChannelsProtein SubunitsASICENaCmechanotransductionoocytesshear stress

Identifiers

PMID42140436
PMCPMC13273826

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.