Evidence map›Paper›PMID 42140432›Full record

ArticleThe Journal of biological chemistry2026

The Ion channel, CFTR, assembles with HIPPO pathway proteins TAZ and YAP in polycystic kidney disease.

Abhishek Sharma, Masoud Afshani, Cristian Ciobanu, Tanvi Sharma, John T Kress, William B Guggino, Liudmila Cebotaru

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Abhishek SharmaDepartments of Medicine and Physiology, Johns Hopkins University, Baltimore, Maryland, USA.
Masoud AfshaniDepartments of Medicine and Physiology, Johns Hopkins University, Baltimore, Maryland, USA.
Cristian CiobanuDepartments of Medicine and Physiology, Johns Hopkins University, Baltimore, Maryland, USA.
Tanvi SharmaDepartments of Medicine and Physiology, Johns Hopkins University, Baltimore, Maryland, USA.
John T KressDepartments of Medicine and Physiology, Johns Hopkins University, Baltimore, Maryland, USA.
William B GugginoDepartments of Medicine and Physiology, Johns Hopkins University, Baltimore, Maryland, USA.
Liudmila CebotaruDepartments of Medicine and Physiology, Johns Hopkins University, Baltimore, Maryland, USA. Electronic address: lcebotaru@jhmi.edu.

Funding

Developing a New Therapeutic Approach for Autosomal Dominant Polycystic Kidney Disease.R01DK125272 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI CEBOTARU, LIUDMILA · 2020 to 2024
$1.9M
NIDDK NIH HHS R01 DK125272
6 · The paper itself

Abstract

Adult-onset polycystic kidney disease (ADPKD) leads to a decline in renal function. Cyst expansion is critically dependent on increased proliferation(1). Because proliferation is so central to cyst formation, thwarting these processes is critical for improving the health of patients with ADPKD. We have shown that the CFTR modulator VX-809 reduces cyst formation by creating an absorptive phenotype and inhibiting proliferation. We utilized the pkd1

Indexed as

Adaptor Proteins, Signal TransducingCystic Fibrosis Transmembrane Conductance RegulatorIntracellular Signaling Peptides and ProteinsPhosphoproteinsPolycystic Kidney DiseasesProtein Serine-Threonine KinasesTranscription FactorsAminopyridinesAnimalsBenzodioxolesCell Cycle ProteinsHippo Signaling PathwayHumansMiceSignal TransductionTrans-ActivatorsAdaptor Proteins, Signal TransducingAminopyridinesBenzodioxolesCell Cycle ProteinsCystic Fibrosis Transmembrane Conductance RegulatorIntracellular Signaling Peptides and ProteinslumacaftorPhosphoproteinsProtein Serine-Threonine KinasesTrans-ActivatorsTranscription FactorsYap1 protein, mouseYAP-Signaling ProteinsADPKDCFTRcystsTAZYAP

Identifiers

PMID42140432
PMCPMC13276344

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.