Evidence map›Paper›PMID 42140429›Full record

ArticleThe Journal of biological chemistry2026

Prion propagation is controlled by discrete structural regions of PrP rather than overall stability.

Savroop K Bhamra, Parineeta Arora, May Liew, Laszlo L P Hosszu, Mark Batchelor, Anthony R Clarke, Jan Bieschke, John Collinge, Parmjit S Jat

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Savroop K BhamraMRC Prion Unit at UCL, UCL Institute of Prion Diseases, London, UK.
Parineeta AroraMRC Prion Unit at UCL, UCL Institute of Prion Diseases, London, UK.
May LiewMRC Prion Unit at UCL, UCL Institute of Prion Diseases, London, UK.
Laszlo L P HosszuMRC Prion Unit at UCL, UCL Institute of Prion Diseases, London, UK.
Mark BatchelorMRC Prion Unit at UCL, UCL Institute of Prion Diseases, London, UK.
Anthony R ClarkeMRC Prion Unit at UCL, UCL Institute of Prion Diseases, London, UK.
Jan BieschkeMRC Prion Unit at UCL, UCL Institute of Prion Diseases, London, UK. Electronic address: j.bieschke@ucl.ac.uk.
John CollingeMRC Prion Unit at UCL, UCL Institute of Prion Diseases, London, UK.
Parmjit S JatMRC Prion Unit at UCL, UCL Institute of Prion Diseases, London, UK. Electronic address: p.jat@ucl.ac.uk.

Funding

Medical Research Council
6 · The paper itself

Abstract

Mutational analysis of the cellular prion protein (PrP

Indexed as

Prion ProteinsPrionsAnimalsMiceMutagenesis, Site-DirectedMutationProtein StabilityPrion ProteinsPrionsalanine site-directed mutagenesisprion propagationprion proteinprotein misfoldingsurface residues

Identifiers

PMID42140429
PMCPMC13264039

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.