Evidence map›Paper›PMID 42140197›Full record

ArticleStem cell reports2026

PrP

Daniel Ojeda-Juarez, Gail Funk, Daniel B McClatchy, Emily Richards, Alexander J Rajic, Katrin Soldau, Michael D Geschwind, Xu Chen, John R Yates, Steven L Gonias and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

  • Update of
    PrP2025
5 · Who and what money

Authors and funding

11 authors.

Daniel Ojeda-JuarezDepartment of Pathology, University of California, San Diego, La Jolla, CA 92093, USA.
Gail FunkDepartment of Pathology, University of California, San Diego, La Jolla, CA 92093, USA.
Daniel B McClatchyDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Emily RichardsDepartment of Pathology, University of California, San Diego, La Jolla, CA 92093, USA.
Alexander J RajicDepartment of Pathology, University of California, San Diego, La Jolla, CA 92093, USA.
Katrin SoldauDepartment of Pathology, University of California, San Diego, La Jolla, CA 92093, USA.
Michael D GeschwindDepartment of Neurology, Weill Institute for Neurosciences, Memory and Aging Center, University of California, San Francisco, San Francisco, CA 94158, USA.
Xu ChenDepartment of Neurosciences, University of California, San Diego, La Jolla, CA 92093, USA.
John R YatesDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Steven L GoniasDepartment of Pathology, University of California, San Diego, La Jolla, CA 92093, USA.
Christina J SigurdsonDepartment of Pathology, University of California, San Diego, La Jolla, CA 92093, USA; Department of Pathology, Immunology, and Microbiology, University of California, Davis, Davis, CA 95616, USA. Electronic address: csigurdson@ucsd.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Synapse loss is an early feature of prion disease, yet the underlying drivers are poorly understood. We recently found evidence of neuronal hyperactivity and synaptic loss in prion-infected mice. Herein, we identified increased Arc/Arg3.1 in patients with prion disease, suggesting heightened neuronal activity also occurs in the human prion-affected brain. To determine the signaling events initiated by prion aggregates (PrP

Indexed as

Induced Pluripotent Stem CellsNerve Tissue ProteinsNeuronsPhospholipase C gammaPrPC ProteinsSignal TransductionAnimalsHumansMicePhosphorylationPrion DiseasesNerve Tissue ProteinsPhospholipase C gammaPrPC ProteinsAlzheimer’s diseaseamyloidCa(2+) signalingCreutzfeldt-Jakob diseaseEGFRneurodegenerationPLC-γ1prion diseaseprotein misfoldingproteomics

Identifiers

PMID42140197
PMCPMC13261956

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.