Evidence map›Paper›PMID 42140192›Full record

ArticleImmunity2026

Aged circulating CD8

Juliana Sucharov, Gregor Bieri, Karishma J B Pratt, Amber R Philp, Turan Aghayev, Shanan Sahota, Laura Remesal, Adam B Schroer, Cedric E Snethlage, Rebecca Chu and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Immune boosting to combat Alzheimer's disease: Position statement.Journal of Alzheimer's disease : JAD · 2026
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Juliana SucharovDepartment of Anatomy, University of California, San Francisco, San Francisco, CA 94143, USA; Biomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, CA 94143, USA.
Gregor BieriDepartment of Anatomy, University of California, San Francisco, San Francisco, CA 94143, USA.
Karishma J B PrattDepartment of Anatomy, University of California, San Francisco, San Francisco, CA 94143, USA; Developmental and Stem Cell Biology Graduate Program, University of California, San Francisco, San Francisco, CA 94143, USA.
Amber R PhilpDepartment of Anatomy, University of California, San Francisco, San Francisco, CA 94143, USA.
Turan AghayevDepartment of Anatomy, University of California, San Francisco, San Francisco, CA 94143, USA.
Shanan SahotaDepartment of Anatomy, University of California, San Francisco, San Francisco, CA 94143, USA.
Laura RemesalDepartment of Anatomy, University of California, San Francisco, San Francisco, CA 94143, USA.
Adam B SchroerDepartment of Anatomy, University of California, San Francisco, San Francisco, CA 94143, USA.
Cedric E SnethlageDepartment of Anatomy, University of California, San Francisco, San Francisco, CA 94143, USA; Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, San Francisco, CA 94143, USA.
Rebecca ChuDepartment of Anatomy, University of California, San Francisco, San Francisco, CA 94143, USA; Biomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, CA 94143, USA.
Zachary J HolmesDepartment of Anatomy, University of California, San Francisco, San Francisco, CA 94143, USA; Biomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, CA 94143, USA.
Julien CouthouisDepartment of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.
Saul A VilledaDepartment of Anatomy, University of California, San Francisco, San Francisco, CA 94143, USA; Biomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, CA 94143, USA; Developmental and Stem Cell Biology Graduate Program, University of California, San Francisco, San Francisco, CA 94143, USA; Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, San Francisco, CA 94143, USA; Department of Physical Therapy and Rehabilitation Science, University of California, San Francisco, San Francisco, CA 94143, USA; Bakar Aging Research Institute, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address: saul.villeda@ucsf.edu.

Funding

Restorative practice in repairing harm and promoting safe and inclusive practices in the laboratory.T32GM136547 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Adrian Erlebacher · 2020 to 2026
$4.5M
Systemic Mechanisms of Brain RejuvenationR01AG077816 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SAUL A VILLEDA · 2022 to 2026
$2.7M
Investigating the role of platelets and platelet-derived factors in rejuvenation of the aged hippocampusF32AG064823 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SCHROER, ADAM · 2019 to 2022
$200k
Investigating the role of the exercise blood factor Gpld1 in restoring brain vasculature function and cognition in agingF32AG081038 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BIERI, GREGOR · 2023 to 2024
$151k
The Role of Peripheral Aged CD8+ T Cells in Hippocampal-Dependent Cognitive DeclineF31AG086042 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Juliana Sucharov Costa · 2024 to 2026
$138k
NIA NIH HHS F31 AG086042NIA NIH HHS F32 AG064823NIA NIH HHS F32 AG081038NIA NIH HHS R01 AG077816NIGMS NIH HHS T32 GM136547
6 · The paper itself

Abstract

Changes in peripheral CD8

Indexed as

AgingCD8-Positive T-LymphocytesCognitive DysfunctionAnimalsGranzymesHippocampusLymphocyte ActivationMaleMiceMice, Inbred C57BLParabiosisGranzymesbrain agingcognitive declinehippocampusimmune agingparabiosisperipheral immune brain cross-talkrejuvenation

Identifiers

PMID42140192
PMCPMC13274914

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.