Evidence map›Paper›PMID 42139971›Full record

ArticleJournal of autoimmunity2026

Runx3 instructs Aire

Jun Hyung Sin, Sloan H Phillips, Audrey V Parent, Michael R Waterfield

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of autoimmunity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jun Hyung SinBiomedical Sciences Graduate Program, University of California San Francisco, San Francisco, CA, USA; Department of Pediatrics, University of California San Francisco, San Francisco, CA, USA.
Sloan H PhillipsDepartment of Pediatrics, University of California San Francisco, San Francisco, CA, USA.
Audrey V ParentDiabetes Center, University of California San Francisco, San Francisco, CA, USA.
Michael R WaterfieldBiomedical Sciences Graduate Program, University of California San Francisco, San Francisco, CA, USA; Department of Pediatrics, University of California San Francisco, San Francisco, CA, USA. Electronic address: Michael.Waterfield@ucsf.edu.

Funding

Regulation of medullary thymic epithelial cells and thymic central tolerance by IkarosR01AI165829 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Michael R Waterfield · 2023 to 2026
$2.7M
NIAID NIH HHS R01 AI165829
6 · The paper itself

Abstract

The transcription factor Runx3 modulates key gene expression programs important for the development of multiple tissues. Here, we uncover new functions for Runx3 in thymic epithelial lineage development and show Runx3 expression in medullary thymic epithelial cells (mTECs) is required for both Autoimmune Regulator + (Aire

Indexed as

Central ToleranceCore Binding Factor Alpha 3 SubunitEpithelial CellsThymus GlandTranscription FactorsAIRE ProteinAnimalsAutoimmunityCell DifferentiationGene Expression RegulationMiceMice, KnockoutAIRE ProteinCore Binding Factor Alpha 3 SubunitRunx3 protein, mouseTranscription Factors

Identifiers

PMID42139971
PMCPMC13297119

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.