ArticlePoultry science2026
Regional expression of neurochemical metabolic pathways in the intestinal tract of the turkey (Meleagris gallopavo domesticus).
Article in Poultry science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Characterization of catecholaminergic and serotonergic pathways in the trachea of the chicken and turkey.Poultry science · 2026Article
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4 authors.
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Abstract
Peripheral monoaminergic systems affect many aspects of poultry physiology and host-microbe interactions relevant to production. While previous studies have elucidated intestinal pathways of monoamine neurochemical synthesis, transport, and catabolism within the chicken and duck, the enteric monoaminergic systems of the turkey remain understudied. As such, the present study sought to determine the presence of monoamine neurochemical enzymes and transporters in different regions of the turkey intestinal tract, and to identify whether there are region-specific differences in expression. To accomplish this, turkeys were raised using age-appropriate conditions until 35 days of age, at which time ileum, ceca, and colon tissues were collected. Within each tissue, we assessed the presence and quantitative expression of monoamine oxidases A and B (MAO-A/B), catechol-O-methyltransferase (COMT), DOPA decarboxylase (DDC), tryptophan hydroxylase-1 (TPH-1), tyrosine hydroxylase (TH), dopamine beta-hydroxylase (DBH), serotonin transporter (SERT), and norepinephrine transporter (NET). While all measured enzymes and transporters were detectable within the ileum, ceca, and colon, region-specific differences in expression profiles were observed. MAO-A, MAO-B and DDC levels were significantly higher (p < 0.05) in the ileum compared to the ceca and colon. Among COMT isoforms, membrane-bound COMT was significantly more abundant than soluble COMT (p < 0.05) among all intestinal regions. Higher DBH expression (p < 0.05) was observed in the ceca compared to other regions while no regional expression differences were observed for TH and TPH-1. NET expression was higher (p < 0.05) in the ceca compared to colon while SERT expression was greater in the ileum compared to the ceca. Together, our data establish the presence of monoaminergic systems in the turkey intestinal tract. That regional differences within the turkey gut regarding expression of key steps in neurochemical pathways were found is in agreement with previously reported findings from the chicken and duck, thereby emphasizing the translational value of enteric monoaminergic systems across poultry species. These findings are expected to enable the development of strategies that seek to control enteric and systemic neurochemical concentrations in turkeys.
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