Evidence map›Paper›PMID 42139701›Full record

ArticleChemistry (Weinheim an der Bergstrasse, Germany)2026

Construction of the Tetracyclic Core of Harziandione via Gold(I) Catalysis.

Jiachen Deng, Ganlin Huang, Jinghan Gui

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jiachen DengState Key Laboratory of Chemical Biology, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.
Ganlin HuangState Key Laboratory of Chemical Biology, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.
Jinghan GuiState Key Laboratory of Chemical Biology, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.ORCID https://orcid.org/0000-0002-4786-5779

Funding

National Key Research and Development Program of China 2021YFF0502400New Cornerstone Science FoundationStrategic Priority Research Program of the Chinese Academy of Sciences XDB1060000Talent Plan of Shanghai Branch, Chinese Academy of Sciences CASSHB-QNPD-2023-009Young Scientists in Basic Research YSBR-095
6 · The paper itself

Abstract

Harziandione is a diterpenoid natural product featuring a 6/5/7/4 tetracyclic core with four contiguous stereocenters, two of which are quaternary. Herein, we report the rapid assembly of its tetracyclic framework in just nine steps from commercially available cyclopentenone, strategically enabled by gold(I) catalysis. The strained bicyclo[5.2.0]nonene motif was assembled via a gold(I)-catalyzed formal [2 + 2] cycloaddition, while the congested bridged [3.2.1] ring system was constructed through a gold(I)-catalyzed Conia-ene reaction. Subsequently, the pivotal C11 enone was installed using a sequence featuring olefin dihydroxylation and Babler-Dauben oxidation as key transformations.

Indexed as

cycloadditionditerpenoidgold catalysisharziandionenatural product synthesis

Identifiers

PMID42139701
PMCPMC13505658

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.