Evidence map›Paper›PMID 42139457›Full record

ArticleThe Journal of organic chemistry2026

Studies toward the Caged Sesquiterpenoid Daphnepapytone A.

Kamar Shakeri, Letizia Lanfredi, Christian Zachau, Luisa Eichner, Iulia Bîlici, Esra Dural, Jan-H Dickoff, Manuela Weber, Mathias Christmann

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of organic chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Studies toward the Caged Sesquiterpenoid Daphnepapytone A.The Journal of organic chemistry · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kamar ShakeriDepartment of Biology, Chemistry, Pharmacy, Institute of Chemistry and Biochemistry, Freie Universität Berlin, Takustraße 3, 14195 Berlin, Germany.
Letizia LanfrediDepartment of Biology, Chemistry, Pharmacy, Institute of Chemistry and Biochemistry, Freie Universität Berlin, Takustraße 3, 14195 Berlin, Germany.
Christian ZachauDepartment of Biology, Chemistry, Pharmacy, Institute of Chemistry and Biochemistry, Freie Universität Berlin, Takustraße 3, 14195 Berlin, Germany.ORCID 0009-0006-2896-2975
Luisa EichnerDepartment of Biology, Chemistry, Pharmacy, Institute of Chemistry and Biochemistry, Freie Universität Berlin, Takustraße 3, 14195 Berlin, Germany.
Iulia BîliciDepartment of Biology, Chemistry, Pharmacy, Institute of Chemistry and Biochemistry, Freie Universität Berlin, Takustraße 3, 14195 Berlin, Germany.
Esra DuralDepartment of Biology, Chemistry, Pharmacy, Institute of Chemistry and Biochemistry, Freie Universität Berlin, Takustraße 3, 14195 Berlin, Germany.
Jan-H DickoffDepartment of Biology, Chemistry, Pharmacy, Institute of Chemistry and Biochemistry, Freie Universität Berlin, Takustraße 3, 14195 Berlin, Germany.
Manuela WeberDepartment of Biology, Chemistry, Pharmacy, Institute of Chemistry and Biochemistry, Freie Universität Berlin, Takustraße 3, 14195 Berlin, Germany.
Mathias ChristmannDepartment of Biology, Chemistry, Pharmacy, Institute of Chemistry and Biochemistry, Freie Universität Berlin, Takustraße 3, 14195 Berlin, Germany.ORCID 0000-0001-9313-2392

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Daphnepapytone A is an unprecedented caged guaiane sesquiterpenoid with α-glucosidase inhibitory activity. We describe progress toward its total synthesis using an α-santonin-type rearrangement strategy. In the course of these studies, a range of guaiane frameworks, including daphbolides A and B, were prepared. However, attempted C9 oxidations of the guaiane proved problematic. Notably, some decalin substrates underwent unexpected rearrangements to yield phenolic products, revealing novel reactivity patterns in this compound class.

Indexed as

Glycoside Hydrolase InhibitorsSesquiterpenesSesquiterpenes, GuaianeMolecular StructureGlycoside Hydrolase InhibitorsSesquiterpenesSesquiterpenes, Guaiane

Identifiers

PMID42139457
PMCPMC13227466

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.