Evidence map›Paper›PMID 42139357›Full record

ArticleScience advances2026

Hcn1-dependent engram neurons in the PVN encode gastric inflammatory sensitization.

E Liu, Xijia Xin, Mengdong Shi, Weikai Han, Qingyu Ren, Yaqi Tang, Yanan Yue, Chenyu Zhang, Zhanpeng Gao, Qingwei Yue and 1 more

Abstract read
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In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

E LiuDepartment of Anatomy and Neurobiology, Shandong University School of Basic Medicine, Jinan, Shandong, China.ORCID 0009-0002-1280-8069
Xijia XinDepartment of Anatomy and Neurobiology, Shandong University School of Basic Medicine, Jinan, Shandong, China.
Mengdong ShiDepartment of Anatomy and Neurobiology, Shandong University School of Basic Medicine, Jinan, Shandong, China.
Weikai HanDepartment of Anatomy and Neurobiology, Shandong University School of Basic Medicine, Jinan, Shandong, China.
Qingyu RenDepartment of Anatomy and Neurobiology, Shandong University School of Basic Medicine, Jinan, Shandong, China.ORCID 0000-0002-0449-5827
Yaqi TangDepartment of Anatomy and Neurobiology, Shandong University School of Basic Medicine, Jinan, Shandong, China.
Yanan YueDepartment of Anatomy and Neurobiology, Shandong University School of Basic Medicine, Jinan, Shandong, China.
Chenyu ZhangDepartment of Anatomy and Neurobiology, Shandong University School of Basic Medicine, Jinan, Shandong, China.
Zhanpeng GaoDepartment of Anatomy and Neurobiology, Shandong University School of Basic Medicine, Jinan, Shandong, China.
Qingwei YueDepartment of Anatomy and Neurobiology, Shandong University School of Basic Medicine, Jinan, Shandong, China.
Jinhao SunDepartment of Anatomy and Neurobiology, Shandong University School of Basic Medicine, Jinan, Shandong, China.ORCID 0000-0001-6470-4312

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The brain encodes peripheral inflammatory signals, but the regulatory mechanism by which the brain controls gastric inflammation remains unclear. This study reveals a circuit through which Fos-positive neurons in the paraventricular nucleus of the hypothalamus (PVN) regulate gastritis via a PVN-dorsal motor nucleus of the vagus-stomach neural circuit and the hypothalamic-pituitary-adrenal (HPA) axis. Using activity-dependent genetic labeling, chemogenetics, and optogenetics, we demonstrate that Fos

Indexed as

GastritisHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsNeuronsParaventricular Hypothalamic NucleusPotassium ChannelsAnimalsInflammationMaleMiceHcn1 protein, mouseHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsPotassium Channels

Identifiers

PMID42139357
PMCPMC13178568

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.