ArticleJournal of extracellular vesicles2026
Current Perspective on Human Milk Derived Vesicles and Their Potential Therapeutic Use: A Scoping Review.
Article in Journal of extracellular vesicles, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Current Perspective on Human Milk Derived Vesicles and Their Potential Therapeutic Use: A Scoping Review.Journal of extracellular vesicles · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human milk-derived extracellular vesicles (HMEVs) recently gained significant attention due to their role in mother-child communication and biomedical application potential. We here provide a systematic scoping review together with interactive figures and comprehensive overview tables summarising the current published knowledge base on HMEVs with a particular perspective on therapeutically relevant aspects, including consensus and divergence of isolation, characterisation, and investigation in preclinical models. Extraction from Embase and MEDLINE and systematic stratification yielded 113 original articles for further analysis. Key themes and emerging issues that became evident included (1) need for more systematic investigation and documentation of basic but essential aspects such as storage, processing parameters and endotoxin levels. (2) Changes of EV concentrations, composition, and potentially also biological activities with gestational age at birth, lactation stage and maternal background need to be taken into consideration to (3) define relevant donor selection criteria. For clinical translation, (4) the definition of mechanisms of action and relevant safety parameters is still lacking while imperative to define critical quality attributes. Eventually, (5) the availability of validated disease models to evaluate therapeutic potency represents a particular challenge for HMEVs since therapeutic approaches inherently focus on infant physiology which is difficult to model in rodents.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.