ReviewCurrent opinion in HIV and AIDS2026
Natural killer cells in pediatric HIV cure strategies: from viral control to immunotherapeutics.
Review in Current opinion in HIV and AIDS, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
3 authors.
Funding
Abstract
purpose of reviewPerinatal HIV infection occurs during a critical window of immune development, in a predominantly naïve immune system, resulting in distinct and unique virologic and immunologic outcomes compared with adult-acquired infection. Innate immunity and specifically natural killer (NK) cells play a role in early viral control and critically shape both size and composition of the HIV reservoir established in infancy. This review examines how NK cell function during acute infection and treatment interruption may contribute to virological outcomes. RECENT
findingsEmerging data show that NK cell phenotypic and functional diversity associates with reservoir size and persistence. Immune-genetic factors, including HLA and KIR interactions and sex-specific differences, can significantly modulate NK-mediated HIV control. Studies also highlight how perinatal HIV exposure and co-infections alter innate immune networks involving monocytes and CD8 T cells, further influencing reservoir dynamics. SUMMARY: Insights into pediatric NK cell immunity reveal unique mechanisms of early HIV control and reservoir shaping that differ from adults. Understanding how NK cell function influences virological outcomes during acute infection and analytic treatment interruption (ATI) provides a critical foundation for designing cure strategies tailored to children. These include leveraging antibody-based interventions and emerging NK-directed immunotherapies to enhance reservoir clearance and support safer, more effective ATI-informed cure approaches.
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