ArticleRevista da Associacao Medica Brasileira (1992)2026
Reduced bone turnover in non-obese women with polycystic ovary syndrome: a cross-sectional study on procollagen-1 N-terminal peptide and beta-C terminal telopeptide.
Article in Revista da Associacao Medica Brasileira (1992), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectivePolycystic ovary syndrome may impair bone metabolism. The aim of this study was to assess serum type-1 collagen N-terminal procollagen and beta-C terminal telopeptide levels in non-obese women with polycystic ovary syndrome.
methodsThis cross-sectional study comprised 174 patients, 18-35 years old. Among the patients with menstrual irregularity, 82 were diagnosed with polycystic ovary syndrome according to the Rotterdam criteria and 92 were in the control group. Women with obesity (BMI>30 kg/m2) were excluded. Hormonal and metabolic parameters, 25-hydroxy vitamin D, procollagen-1 N-terminal peptide, and beta-C terminal telopeptide levels were measured.
resultsDemographics and most biochemical parameters were comparable between groups. Polycystic ovary syndrome patients had significantly lower 25-hydroxy vitamin D (80.12±68.00 vs. 117.08±73.92 ng/mL, p=0.010), procollagen-1 N-terminal peptide (597.36±501.49 vs. 863.47±509.01 ng/mL, p=0.013), and beta-C terminal telopeptide (572.88±585.94 vs. 929.91±641.38 ng/L, p=0.004) levels compared with controls.
conclusionNon-obese women with polycystic ovary syndrome show significantly reduced bone formation and resorption markers, suggesting adverse effects on bone turnover. These findings suggest a low-turnover bone state in non-obese polycystic ovary syndrome women.
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