Evidence map›Paper›PMID 42138826›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Sulfated Cyclocarya Paliurus Polysaccharide Sorchestrates the Gut Microbiome to Mobilize a Host-Derived 12-HEPE Against Ulcerative Colitis.

Xianxiang Chen, Mingyue Shen, Rui Zhang, Zhibing Huang, Hui Niu, Qiang Yu, Yi Chen, Xiangwen Pan, Liyuan Rong, Huiliang Wen and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Xianxiang ChenState Key Laboratory of Food Science and Resources, Nanchang University, Nanchang, China.
Mingyue ShenState Key Laboratory of Food Science and Resources, Nanchang University, Nanchang, China.
Rui ZhangDepartment of Clinical Laboratory Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
Zhibing HuangState Key Laboratory of Food Science and Resources, Nanchang University, Nanchang, China.
Hui NiuDepartment of Wood Science, The University of British Columbia, Vancouver, Canada.
Qiang YuState Key Laboratory of Food Science and Resources, Nanchang University, Nanchang, China.ORCID https://orcid.org/0000-0003-3182-2472
Yi ChenState Key Laboratory of Food Science and Resources, Nanchang University, Nanchang, China.ORCID https://orcid.org/0009-0004-9302-0138
Xiangwen PanState Key Laboratory of Food Science and Resources, Nanchang University, Nanchang, China.
Liyuan RongState Key Laboratory of Food Science and Resources, Nanchang University, Nanchang, China.
Huiliang WenState Key Laboratory of Food Science and Resources, Nanchang University, Nanchang, China.
Jun YangState Key Laboratory of Food Science and Resources, Nanchang University, Nanchang, China.
Jianhua XieState Key Laboratory of Food Science and Resources, Nanchang University, Nanchang, China.ORCID https://orcid.org/0000-0002-3906-1260

Funding

National Key Research and Development Program of China 2023YFF1104001National Natural Science Foundation of China 82460642
6 · The paper itself

Abstract

Despite extensive evidence supporting the therapeutic potential of natural product-derived compounds in Ulcerative colitis (UC), their precise mechanisms have yet to be fully elucidated. In this study, structurally modified Cyclocarya paliurus polysaccharide (CP) derivatives were evaluated in a dextran sulfate sodium (DSS)-induced UC mouse model. Among the variants tested, sulfated Cyclocarya paliurus polysaccharide (SCP) emerged as the most therapeutically potent. SCP administration markedly attenuated colitis severity, as evidenced by relieved disease symptoms and reinforced intestinal barrier function. Mechanistically, SCP restored gut microbial homeostasis by enriching beneficial Bacteroidetes and enhancing short-chain fatty acids (SCFAs) production. This remodeled microbial ecosystem orchestrates the upregulation of host-derived 12-hydroxyeicosapentaenoic acid (12-HEPE), which exerts anti-inflammatory effects via direct inhibition of Toll-like receptor 4 (TLR4) signaling. The gut microbiota's functional relevance was substantiated by fecal microbiota transplantation and antibiotic-mediated exhaustion studies. Notably, the therapeutic benefits of 12-HEPE were abrogated upon co-administration of a TLR4 agonist, confirming its target specificity. Elevated serum 12-HEPE levels were observed in a human UC cohort, implying a potential compensatory immunoregulatory response. Our findings elucidate a novel microbiota-host interaction axis wherein SCP alleviates UC by modulating the gut microbiota to enhance endogenous 12-HEPE production, thereby suppressing TLR4-mediated inflammation.

Indexed as

Colitis, UlcerativeGastrointestinal MicrobiomeJuglandaceaePolysaccharidesAnimalsDextran SulfateDisease Models, AnimalMaleMiceMice, Inbred C57BLToll-Like Receptor 4Dextran SulfatePolysaccharidesToll-Like Receptor 4Cyclocarya paliurus polysaccharidemicrobiota, TLR4UC

Identifiers

PMID42138826
PMCPMC13336020

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.