Quantitative ventricular trabeculation assessment in cardiac MRI: optimised blood-pool segmentation, box-counting fractal analysis and non-fractal measurements.

Jan Sedlacik, Kathryn A McGurk, Paweł F Tokarczuk, Ben Statton, Alaine Berry, Massimo Marenzana, Declan P O'Regan

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Article in The international journal of cardiovascular imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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7 authors.

Jan SedlacikMedical Research Council, Laboratory of Medical Sciences, London, UK.

Kathryn A McGurkMedical Research Council, Laboratory of Medical Sciences, London, UK.

Paweł F TokarczukMedical Research Council, Laboratory of Medical Sciences, London, UK.

Ben StattonMedical Research Council, Laboratory of Medical Sciences, London, UK.

Alaine BerryMedical Research Council, Laboratory of Medical Sciences, London, UK.

Massimo MarenzanaMedical Research Council, Laboratory of Medical Sciences, London, UK.

Declan P O'ReganMedical Research Council, Laboratory of Medical Sciences, London, UK. declan.oregan@imperial.ac.uk.

Funding

British Heart Foundation FS/IPBSRF/22/27059, RE/18/4/34215British Heart Foundation RG/19/6/34387, RE/18/4/34215, CH/P/23/80008Medical Research Council MC_UP_1605/13

6 · The paper itself

Abstract

Quantitative assessment of the ventricular trabeculation by fractal dimension (FD) involves complex processing steps which may impact the results. We optimised the automated processing workflow for a reliable assessment of the left and right ventricles at end-diastole and end-systole which is suitable for the automated analysis of large-scale cohorts. Ventricular trabeculae and blood were segmented using a level-set method optimised to exclude pixels outside the heart on short-axis cardiac MRI. FD was derived by box-counting the trabeculae/blood boundary while investigating the impact of box size, sampling and rotation. Alternative non-fractal measures - the convexity related boundary length ratio (BLR) and the trabeculated mass ratio (TMR) - were also investigated.FD values with and without optimisation showed a strong linear correlation (R

Indexed as

FractalsHeart VentriclesImage Interpretation, Computer-AssistedMagnetic Resonance Imaging, CineVentricular Function, LeftVentricular Function, RightHumansPredictive Value of TestsReproducibility of ResultsWorkflowBoundary length ratioBox-countingConvexityFractal dimensionLevel-setTrabeculated ventricular mass

Identifiers

PMID42138799

DOI10.1007/s10554-026-03687-9

PMCPMC13375774

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