Evidence map›Paper›PMID 42138735›Full record

ArticleNeuroradiology2026

Association between posterior cerebral artery involvement and arterial wall enhancement in moyamoya disease: a cross-sectional study with vessel wall imaging.

Takeshi Funaki, Hideo Chihara, Tomoki Sasagasako, Masakazu Okawa, Yohei Mineharu, Yasutaka Fushimi, Sachi Okuchi, Kentaro Ueno, John Grinstead, Sinyeob Ahn and 4 more

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Article in Neuroradiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

14 authors.

Takeshi FunakiDepartment of Neurosurgery, Kyoto University, Kyoto, Japan. tfunaki@kuhp.kyoto-u.ac.jp.
Hideo ChiharaDepartment of Neurosurgery, Kyoto University, Kyoto, Japan.
Tomoki SasagasakoDepartment of Neurosurgery, Kyoto University, Kyoto, Japan.
Masakazu OkawaDepartment of Neurosurgery, Kyoto University, Kyoto, Japan.
Yohei MineharuDepartment of Neurosurgery, Kyoto University, Kyoto, Japan.
Yasutaka FushimiDepartment of Diagnostic Imaging and Nuclear Medicine, Kyoto University, Kyoto, Japan.
Sachi OkuchiDepartment of Advanced Imaging in Medical Magnetic Resonance, Kyoto University, Kyoto, Japan.
Kentaro UenoDepartment of Biomedical Statistics and Bioinformatics, Kyoto University, Kyoto, Japan.
John GrinsteadSiemens Healthineers (United States), Malvern, USA.
Sinyeob AhnSiemens Healthineers (United States), Malvern, USA.
Alto StemmerSiemens Healthineers (Germany), Erlangen, Germany.
Taichi IkedoDepartment of Neurosurgery, Kyoto University, Kyoto, Japan.
Hiroyuki IkedaDepartment of Neurosurgery, Kyoto University, Kyoto, Japan.
Yoshiki ArakawaDepartment of Neurosurgery, Kyoto University, Kyoto, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeEarly detection and activity assessment of posterior cerebral artery (PCA) involvement in moyamoya disease (MMD) are challenging. We aimed to assess the cross-sectional association between PCA involvement and PCA wall enhancement on vessel wall MRI (DANTE T1-SPACE).

methodsWe analyzed consecutive patients with MMD who underwent both non-contrast-enhanced and contrast-enhanced DANTE T1-SPACE. Positive wall enhancement was defined as location-appropriate arterial wall enhancement with an enhancement ratio ≥ 1.5. PCA involvement was graded 0-2 on MRA obtained during the same period.

resultsOf 368 hemispheres from 184 patients, 56 (15.2%) showed PCA involvement and 17 (4.6%) showed PCA wall enhancement. PCA involvement was present in 94.1% of enhancement-positive hemispheres versus 11.4% of enhancement-negative hemispheres (p < 0.001). The difference was consistent across age, Suzuki stage, and RNF213 genotype strata. Enhancement most often involved the P2A segment. Topographical correspondence between enhancement and the stenoocclusive lesion was excellent (overall percent agreement, 94.1%). PCA wall enhancement was observed in 0.3%, 61.5%, and 18.6% of hemispheres with grade 0, 1, and 2 PCA involvement, respectively. Positive enhancement was more frequent in grade 1 PCA involvement than in grade 2 (adjusted p = 0.02).

conclusionsStatistical and topographical findings suggest a strong cross-sectional association between PCA involvement and PCA wall enhancement. The enhancement may be associated with disease activity and may facilitate detection of early-stage PCA involvement with high specificity; these hypotheses require confirmation in longitudinal cohorts.

Indexed as

DANTEMagnetic resonance imagingMoyamoya diseasePosterior cerebral arteryVascular wall

Identifiers

PMID42138735

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