ArticleInternational journal of surgical pathology2026
A Periadrenal Gland Ewing Sarcoma With Extensive Posttreatment Ganglioneuroblastoma-Like Morphology in an Adult Patient.
Article in International journal of surgical pathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Neuroblastoma and Ewing sarcoma are two round cell malignancies that can exhibit light microscopic overlap and potentially arise in the same anatomic location, leading to diagnostic uncertainty. Neoadjuvant chemotherapy-induced cytodifferentiation/maturation is a common feature in pediatric malignancies, whereas Ewing sarcomas often exhibit variable degrees of necrosis, inflammatory infiltrates, and stromal fibrosis after neoadjuvant treatment. Posttreatment neuroblastoma-like morphologic changes have been rarely reported in pediatric Ewing sarcoma. Herein, we report a 33-year-old man with a retroperitoneal periadrenal mass and normal plasma catecholamine levels. The tumor biopsy demonstrated Homer-Wright rosette-forming small round cells with a high nuclear-to-cytoplasmic ratio and finely granular chromatin. The tumor cells showed strong, diffuse membranous CD99 and nuclear NKX2.2 expression, whereas they were negative for PHOX2B, a neuroblastoma/ganglion cell marker.
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