Evidence map›Paper›PMID 42138479›Full record

ArticleChemistry & biodiversity2026

Cytotoxic Quassinoids From the Leaves of Ailanthus altissima.

Ming-Hui Li, Meng-Jie He, Ming-Jie Huang, Xue-Lian Tang, Hua Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ming-Hui LiSchool of Biological Science and Technology, University of Jinan, Jinan, China.
Meng-Jie HeSchool of Biological Science and Technology, University of Jinan, Jinan, China.
Ming-Jie HuangSchool of Biological Science and Technology, University of Jinan, Jinan, China.
Xue-Lian TangSchool of Biological Science and Technology, University of Jinan, Jinan, China.ORCID https://orcid.org/0000-0001-7753-6661
Hua ZhangSchool of Biological Science and Technology, University of Jinan, Jinan, China.ORCID https://orcid.org/0000-0002-5959-6473

Funding

Jinan University XBS2441
6 · The paper itself

Abstract

Ten quassinoid-type compounds, including two previously undescribed ones (1 and 2), were isolated from the leaves of Ailanthus altissima. Structures of the new quassinoids were unambiguously elucidated through comprehensive spectroscopic analysis, with their absolute configurations further confirmed by single-crystal x-ray diffraction, TD-DFT/ECD calculation, and chemical correlation with known analogues. Preliminary in vitro cell viability assay revealed that compound 1 exhibited significant cytotoxic activity against MDA-MB-231, A549, MCF-7, and 4T1 tumor cell lines, with IC

Indexed as

AilanthusAntineoplastic Agents, PhytogenicPlant LeavesQuassinsApoptosisCell Line, TumorCell ProliferationCell SurvivalDose-Response Relationship, DrugDrug Screening Assays, AntitumorHumansMolecular ConformationMolecular StructureStructure-Activity RelationshipAntineoplastic Agents, PhytogenicQuassinsAilanthus altissimacytotoxicityquassinoidsSimaroubaceae

Identifiers

PMID42138479
PMCPMC13376718

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.