Evidence map›Paper›PMID 42138379›Full record

ReviewJournal of virology2026

Open questions in enterovirus uncoating.

Walker Symonds-Orr, Patrick T Dolan

Abstract readReview
In one paragraph

Review in Journal of virology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Walker Symonds-OrrQuantitative Virology and Evolution Unit, Laboratory of Viral Diseases, NIH-NIAID Division of Intramural Research, Bethesda, Maryland, USA.ORCID 0000-0002-3769-2050
Patrick T DolanQuantitative Virology and Evolution Unit, Laboratory of Viral Diseases, NIH-NIAID Division of Intramural Research, Bethesda, Maryland, USA.ORCID 0000-0002-4169-0058

Funding

NHLBI NIH HHS 1ZIAAI001360
6 · The paper itself

Abstract

Enterovirus uncoating, the events leading to the release of the viral genome into the cytoplasm, remains a poorly understood process. This review discusses two competing models: the "genome translocation model," where viral proteins form a pore for RNA passage into the cytosol, and the "particle escape model," where the entire virion crosses the endosomal membrane before uncoating. We discuss the combination of structural biology,

Indexed as

EnterovirusEnterovirus InfectionsVirus UncoatingAnimalsEndosomesGenome, ViralHumansRNA, ViralVirionVirus InternalizationRNA, Viralendosomesenterovirusespicornavirusvirion structurevirus entry

Identifiers

PMID42138379
PMCPMC13288840

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.