Evidence map›Paper›PMID 42138352›Full record

ArticleeLife2026

Drug-induced changes in connectivity to midbrain dopamine cells revealed by rabies monosynaptic tracing.

Katrina Bartas, Pieter Derdeyn, Guilian Tian, Jose J Vasquez, Ghalia Azouz, Cindy M Yamamoto, May Hui, Kevin T Beier

Abstract read
In one paragraph

Article in eLife, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Neural basis of adolescent THC-induced potentiation of opioid responses later in life.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Katrina BartasProgram in Mathematical, Computational, and Systems Biology, University of California, Irvine, Irvine, United States.
Pieter DerdeynProgram in Mathematical, Computational, and Systems Biology, University of California, Irvine, Irvine, United States.ORCID https://orcid.org/0000-0002-1545-5572
Guilian TianDepartment of Physiology and Biophysics, University of California, Irvine, Irvine, United States.
Jose J VasquezDepartment of Physiology and Biophysics, University of California, Irvine, Irvine, United States.ORCID https://orcid.org/0000-0002-4922-1520
Ghalia AzouzDepartment of Physiology and Biophysics, University of California, Irvine, Irvine, United States.
Cindy M YamamotoDepartment of Physiology and Biophysics, University of California, Irvine, Irvine, United States.
May HuiDepartment of Physiology and Biophysics, University of California, Irvine, Irvine, United States.ORCID https://orcid.org/0000-0002-6231-7383
Kevin T BeierDepartment of Physiology and Biophysics, University of California, Irvine, Irvine, United States.ORCID https://orcid.org/0000-0002-4934-1338

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM008620 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI GOLDIN, ALAN L · 1999 to 2023
$8.1M
Circuitry dynamics underlying opioid-dependence: Integrating structural, functional, and transcriptomic mechanismsR01DA056599 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI KEVIN T BEIER, Julie A Blendy · 2022 to 2026
$3.8M
Sculpting the brain: High-resolution spatiotemporally-controlled modulation of memoriesDP2AG067666 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI BEIER, KEVIN T, CORDER, GREGORY · 2019 to 2022
$3.1M
Mentor Training to enhance mentorship in an interdisciplinary training programT32GM136624 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI Arthur D Lander, Qing Nie · 2020 to 2026
$3.1M
Mapping opioid-dependence state transitions across structural, functional, and transcriptomic topologiesR01DA054374 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI BLENDY, JULIE A, CORDER, GREGORY · 2021 to 2025
$2.4M
Investigation of neural ensembles driving pain chronificationR01NS130044 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI KEVIN T BEIER, Gregory Corder · 2023 to 2026
$1.4M
INVESTIGATING FUNCTION OF NOVEL DRUG-INDUCED SYNAPTIC CHANGES IN THE VTAR00DA041445 · NIDA · UNIVERSITY OF CALIFORNIA-IRVINE · PI BEIER, KEVIN T · 2018 to 2020
$747k
Investigation of neural ensembles underlying chronic painF30DA056215 · NIDA · UNIVERSITY OF CALIFORNIA-IRVINE · PI May Hui · 2022 to 2026
$189k
Alzheimer's Association AARG-NTF-20-685694American Parkinson Disease Association APDA-5589562Brain and Behavior Research Foundation NARSAD 26845BrightFocus Foundation A2022031SNational Science Foundation GRFP DGE-1839285New Vision Research CCAD2020-002NIH HHS DP2 AG067666NIH HHS F30 DA056215NIH HHS R00 DA041445NIH HHS R01 DA054374NIH HHS R01 DA056599NIH HHS R01 NS130044NIH HHS T32 GM008620NIH HHS T32 GM136624Tobacco-Related Disease Research Program T31KT1437Tobacco-Related Disease Research Program T31P1426
6 · The paper itself

Abstract

Addictive drugs cause long-lasting changes in connectivity from inputs onto ventral tegmental area dopamine cells (VTA

Indexed as

Dopaminergic NeuronsMesencephalonRabies virusAnimalsMaleMiceMice, Inbred C57BLaddictive drugscellular activityconnectomicsinput mappingketamine/xylazinemouseneurosciencerabies virus

Identifiers

PMID42138352
PMCPMC13179063

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.