Evidence map›Paper›PMID 42138350›Full record

ArticleReproduction & fertility2026

Embryo transfer following IVF alters susceptibility to metabolic phenotypes in male mouse offspring compared to naturally conceived offspring.

Katharina Laurent, Sandra Hoffmann, Susan Marschall, Kerstin B Richter, Raffaele Teperino, Martin Hrabě de Angelis, David A Skerrett-Byrne, Johannes Beckers

Abstract read
In one paragraph

Article in Reproduction & fertility, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Katharina LaurentInstitute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health Neuherberg, Neuherberg, Germany.ORCID https://orcid.org/0009-0004-8348-8650
Sandra HoffmannInstitute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health Neuherberg, Neuherberg, Germany.
Susan MarschallInstitute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health Neuherberg, Neuherberg, Germany.
Kerstin B RichterInstitute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health Neuherberg, Neuherberg, Germany.
Raffaele TeperinoInstitute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health Neuherberg, Neuherberg, Germany.
Martin Hrabě de AngelisInstitute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health Neuherberg, Neuherberg, Germany.
David A Skerrett-ByrneInstitute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health Neuherberg, Neuherberg, Germany.ORCID https://orcid.org/0000-0002-1804-1826
Johannes BeckersInstitute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health Neuherberg, Neuherberg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lay summary: The aim of this study is to highlight potential differences between embryos conceived naturally and those conceived via in vitro fertilisation (IVF). While the current scientific literature generally assumes that differences between these two modes of conception exist, many studies do not provide detailed phenotypic data, e.g. bodyweight, blood glucose and other observational metabolic health parameters. In addition, comparisons are often complicated by variations in choosing different strains of foster mothers to carry embryos. By addressing these limitations, our short summary and overview provide a well-defined comparison within a controlled experimental setup including a high-fat diet feeding period as metabolic challenge. We make the resulting data publicly available to offer a reference point for researchers using a specific mouse strain as fosters and to improve transparency regarding the specific differences in metabolic health observed between natural conception and IVF in this context.

Indexed as

Embryo TransferFertilizationFertilization in VitroAnimalsDiet, High-FatFemaleMaleMicePhenotypePregnancyIVFmetabolismoffspring

Identifiers

PMID42138350
PMCPMC13232599

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.