Evidence map›Paper›PMID 42138345›Full record

ArticleBiopolymers2026

Detection of a Target Nucleic Acid by Ligation-Assisted Fluorescence Enhancement of a Peptide Nucleic Acid (PNA) Twin Probe via Disulfide Binding.

Yutaka Ouchi, Koki Ishii, Yumiko Sato, Yoshitane Imai, Hideo Matsui, Takashi Ohtsuki, Yoshiyuki Hakata, Hajime Shigeto, Shohei Yamamura, Mizuki Kitamatsu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biopolymers, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yutaka OuchiDepartment of Applied Chemistry, Kindai University, Higashiosaka, Japan.
Koki IshiiDepartment of Applied Chemistry, Kindai University, Higashiosaka, Japan.
Yumiko SatoDepartment of Applied Chemistry, Kindai University, Higashiosaka, Japan.
Yoshitane ImaiDepartment of Applied Chemistry, Kindai University, Higashiosaka, Japan.ORCID https://orcid.org/0000-0003-4415-7432
Hideo MatsuiDepartment of Applied Chemistry, Kindai University, Higashiosaka, Japan.ORCID https://orcid.org/0009-0002-3994-6162
Takashi OhtsukiDepartment of Interdisciplinary Science and Engineering in Health Systems, Okayama University, Okayama, Japan.ORCID https://orcid.org/0000-0002-3183-5305
Yoshiyuki HakataDepartment of Arts and Sciences, Faculty of Medicine, Kindai University, Sakai, Japan.ORCID https://orcid.org/0000-0003-3748-016X
Hajime ShigetoHealth and Medical Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Takamatsu, Japan.ORCID https://orcid.org/0000-0003-0602-8736
Shohei YamamuraHealth and Medical Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Takamatsu, Japan.ORCID https://orcid.org/0000-0002-4971-4560
Mizuki KitamatsuDepartment of Applied Chemistry, Kindai University, Higashiosaka, Japan.ORCID https://orcid.org/0000-0001-8643-8238

Funding

Kindai University IP009
6 · The paper itself

Abstract

The development of methods for detecting specific nucleic acids is important for early diagnosis and treatment of diseases at the genetic level. We have developed a pair of pyrene (Pyr)-modified peptide nucleic acids (PNAs), PNA twin probe, as a tool for such detection. In this study, we prepared Pyr-PNAs containing chloroacetyl (-COCH

Indexed as

DisulfidesFluorescent DyesPeptide Nucleic AcidsRNAFluorescenceFluorescent Chemosensor CompoundsHumansPyrenesSpectrometry, FluorescenceDisulfidesFluorescent Chemosensor CompoundsFluorescent DyesPeptide Nucleic AcidspyrenePyrenesRNAcell‐penetrating peptidedisulfide crosslinkingfluorescent probepeptide nucleic acidpyrene

Identifiers

PMID42138345
PMCPMC13178207

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.