ReviewBiochemical Society transactions2026
Direct or indirect: the crucial role of N-palmitate in hedgehog signaling.
Review in Biochemical Society transactions, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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2 authors.
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Abstract
During development, cells use concentration gradients of soluble signaling molecules, called morphogens, to determine their position within tissues and adopt the correct identity. Hedgehog (Hh) morphogens are a key but also unusual example of gradient formation, because their diffusion away from their origin to direct growth and patterning is first prevented by their dual N- and C-terminal lipidation by palmitate and cholesterol. These lipids associate the Hhs with the plasma membrane of the cells that produce them. Later, however, both lipids participate in the spatiotemporal release of Hh by accessory proteins and maintain Hh biofunction in vivo, either directly or indirectly. The present study explores these two mechanistic possibilities, focusing on the central role of N-palmitate in Hh-regulated development in both vertebrates and invertebrates.
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