Evidence map›Paper›PMID 42138056›Full record

ArticleSmall (Weinheim an der Bergstrasse, Germany)2026

NIR-II Fluorescent Nanoplatforms with Defect-Regulated Piezoelectricity for Dual NIR-II/MRI-Guided, Hypoxia-Resilient Piezo-Chemodynamic Therapy and cGAS-STING Activation in Orthotopic Liver Tumor.

Shubham Roy, Ni Shao, Xiyu Wei, Pingping Zhang, Jun Su, Muhammad Madni, Zia Ullah, Yinbin Yan, Yuqian Yan, Jhilik Roy and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Small (Weinheim an der Bergstrasse, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Emerging Nanoplatforms are Effective Against Tumor Hypoxia.International journal of nanomedicine · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Shubham RoySchool of Science, Harbin Institute of Technology, Shenzhen, Guangdong, China.
Ni ShaoThe Guangzhou Key Laboratory of Molecular and Functional Imaging For Clinical Translation Department of Radiology and Nuclear Medicine, The First Affiliated Hospital of Jinan University, Guangzhou, China.
Xiyu WeiEducation Center and Experiments and Innovations, Harbin Institute of Technology, Shenzhen, China.
Pingping ZhangThe Guangzhou Key Laboratory of Molecular and Functional Imaging For Clinical Translation Department of Radiology and Nuclear Medicine, The First Affiliated Hospital of Jinan University, Guangzhou, China.
Jun SuThe Guangzhou Key Laboratory of Molecular and Functional Imaging For Clinical Translation Department of Radiology and Nuclear Medicine, The First Affiliated Hospital of Jinan University, Guangzhou, China.
Muhammad MadniSchool of Science, Harbin Institute of Technology, Shenzhen, Guangdong, China.
Zia UllahSchool of Science, Harbin Institute of Technology, Shenzhen, Guangdong, China.
Yinbin YanSchool of Science, Harbin Institute of Technology, Shenzhen, Guangdong, China.
Yuqian YanSchool of Science, Harbin Institute of Technology, Shenzhen, Guangdong, China.
Jhilik RoyDepartment of Physics, Jadavpur University, Kolkata, India.
Amartya SauDepartment of Physics, Jadavpur University, Kolkata, India.
Ting KuangEducation Center and Experiments and Innovations, Harbin Institute of Technology, Shenzhen, China.
Lihong JiangEducation Center and Experiments and Innovations, Harbin Institute of Technology, Shenzhen, China.
Zeyu XiaoThe Guangzhou Key Laboratory of Molecular and Functional Imaging For Clinical Translation Department of Radiology and Nuclear Medicine, The First Affiliated Hospital of Jinan University, Guangzhou, China.
Cuiqing HuangThe Guangzhou Key Laboratory of Molecular and Functional Imaging For Clinical Translation Department of Radiology and Nuclear Medicine, The First Affiliated Hospital of Jinan University, Guangzhou, China.ORCID https://orcid.org/0009-0000-3610-9938
Bing GuoSchool of Science, Harbin Institute of Technology, Shenzhen, Guangdong, China.ORCID https://orcid.org/0000-0001-7981-0644

Funding

Guangdong Basic and Applied Basic Research Foundation 2023A1515220128Guangdong Basic and Applied Basic Research Foundation 2025A1515011922Guangdong Basic and Applied Basic Research Foundation 2026A1515010456Institutional Animal Research Committee IACUC-20240905-05Jinan UniversityMinistry of Human Resources and Social Security and Ministry of Education Y20250002National Foreign Expert Individual ProjectShenzhen High-Level Talent ProgramSpecial Foundation for General Basic Research Program of Shenzhen JCYJ20240813105122030
6 · The paper itself

Abstract

The development of multifunctional theranostic nanoplatforms with second near-infrared (NIR-II) fluorescence and magnetic resonance imaging (MRI), which enable deep-tissue imaging, hypoxia-tolerant ROS generation via on-demand, rapid piezodynamic therapy (PZDT) and sustained tumor-microenvironment-activated chemodynamic therapy (CDT), together with robust immunomodulation, remains a critical challenge in tumor therapy. Here, one-pot solvothermal synthesis of Mn, Yb, and Er co-doped BaTiO

Indexed as

Liver NeoplasmsMagnetic Resonance ImagingMembrane ProteinsNanoparticlesNucleotidyltransferasesAnimalsCell Line, TumorcGAS-STING Signaling PathwayCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseHumansInfrared RaysMiceSTING ProteinCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseMembrane ProteinsNucleotidyltransferasesSTING ProteincGAS‐STING activationNIR‐II fluorescence imagingpiezo‐chemodynamic therapypiezodynamic therapytumor hypoxia

Identifiers

PMID42138056
PMCPMC13351504

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.