ReviewMacromolecular bioscience2026
Recent Advances in Natural Polymers-based Hydrogels for Periodontal Regeneration.
Review in Macromolecular bioscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Conventional therapies still provide only limited true tissue regeneration for periodontal diseases, particularly periodontitis, which are highly prevalent chronic inflammatory conditions associated with irreversible loss of tooth-supporting tissues and relevant systemic consequences. In this context, hydrogels based on natural polymers have been widely explored in periodontal tissue engineering as biomimetic matrices capable of modulating the inflammatory response, enabling localized delivery of bioactive agents, and offering temporary structural support. This review summarizes recent advances in hydrogels composed of alginate, collagen, chitosan, and other natural or semi-synthetic polymers applied to periodontal regeneration. The influence of polymer origin, crosslinking strategies, physicochemical and rheological properties, and processing approaches, including injectable formulations, self-healing systems, and bioinks for three-dimensional bioprinting, is discussed in relation to cell adhesion, angiogenesis, osteogenesis, and functional restoration of periodontal tissues. Hybrid platforms such as interpenetrating polymer networks, ceramic-reinforced composites, and systems designed for controlled delivery of drugs, growth factors, exosomes, and stem cells are also examined, with emphasis on immunomodulatory and stimuli-responsive designs tailored to the periodontal microenvironment. Despite robust preclinical evidence demonstrating coordinated regeneration of cementum, periodontal ligament, and alveolar bone, major challenges remain. These include the scarcity of well-controlled clinical trials, limitations in standardization, and regulatory barriers to translation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.