Article in Circulation research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Asli E AticiDepartment of Pediatrics, Cedars-Sinai Guerin Children's (A.E.A., P.K.J., T.T.C., B.L.R., E.A.A., M.E.L., A.C.G., Y.L., S.C., T.R.C., M.A., M.N.R.), Cedars‑Sinai Health Sciences University, Los Angeles, CA.ORCID 0000-0003-1546-7191
Prasant K JenaDepartment of Pediatrics, Cedars-Sinai Guerin Children's (A.E.A., P.K.J., T.T.C., B.L.R., E.A.A., M.E.L., A.C.G., Y.L., S.C., T.R.C., M.A., M.N.R.), Cedars‑Sinai Health Sciences University, Los Angeles, CA.ORCID 0000-0002-6729-5881
Thacyana T CarvalhoDepartment of Pediatrics, Cedars-Sinai Guerin Children's (A.E.A., P.K.J., T.T.C., B.L.R., E.A.A., M.E.L., A.C.G., Y.L., S.C., T.R.C., M.A., M.N.R.), Cedars‑Sinai Health Sciences University, Los Angeles, CA.ORCID 0000-0002-8580-6200
Benjamin L RossDepartment of Pediatrics, Cedars-Sinai Guerin Children's (A.E.A., P.K.J., T.T.C., B.L.R., E.A.A., M.E.L., A.C.G., Y.L., S.C., T.R.C., M.A., M.N.R.), Cedars‑Sinai Health Sciences University, Los Angeles, CA.
Emily A AubuchonDepartment of Pediatrics, Cedars-Sinai Guerin Children's (A.E.A., P.K.J., T.T.C., B.L.R., E.A.A., M.E.L., A.C.G., Y.L., S.C., T.R.C., M.A., M.N.R.), Cedars‑Sinai Health Sciences University, Los Angeles, CA.ORCID 0009-0009-5044-5722
Malcolm E LaneDepartment of Pediatrics, Cedars-Sinai Guerin Children's (A.E.A., P.K.J., T.T.C., B.L.R., E.A.A., M.E.L., A.C.G., Y.L., S.C., T.R.C., M.A., M.N.R.), Cedars‑Sinai Health Sciences University, Los Angeles, CA.
Angela C GomezDepartment of Pediatrics, Cedars-Sinai Guerin Children's (A.E.A., P.K.J., T.T.C., B.L.R., E.A.A., M.E.L., A.C.G., Y.L., S.C., T.R.C., M.A., M.N.R.), Cedars‑Sinai Health Sciences University, Los Angeles, CA.ORCID 0000-0001-7019-9607
Youngho LeeDepartment of Pediatrics, Cedars-Sinai Guerin Children's (A.E.A., P.K.J., T.T.C., B.L.R., E.A.A., M.E.L., A.C.G., Y.L., S.C., T.R.C., M.A., M.N.R.), Cedars‑Sinai Health Sciences University, Los Angeles, CA.ORCID 0000-0002-5227-683X
Michael C FishbeinDepartment of Pathology and Laboratory Medicine, David Geffen School of Medicine (M.C.F.), University of California, Los Angeles.ORCID 0000-0002-6591-6306
Joshua AzerSmidt Heart Institute (J.A., T.M., M.A.), Cedars‑Sinai Health Sciences University, Los Angeles, CA.
Thassio MesquitaSmidt Heart Institute (J.A., T.M., M.A.), Cedars‑Sinai Health Sciences University, Los Angeles, CA.ORCID 0000-0002-6927-5745
Shuang ChenDepartment of Pediatrics, Cedars-Sinai Guerin Children's (A.E.A., P.K.J., T.T.C., B.L.R., E.A.A., M.E.L., A.C.G., Y.L., S.C., T.R.C., M.A., M.N.R.), Cedars‑Sinai Health Sciences University, Los Angeles, CA.ORCID 0000-0002-2919-4967
Timothy R CrotherDepartment of Pediatrics, Cedars-Sinai Guerin Children's (A.E.A., P.K.J., T.T.C., B.L.R., E.A.A., M.E.L., A.C.G., Y.L., S.C., T.R.C., M.A., M.N.R.), Cedars‑Sinai Health Sciences University, Los Angeles, CA.ORCID 0000-0001-8465-6127
Moshe ArditiDepartment of Pediatrics, Cedars-Sinai Guerin Children's (A.E.A., P.K.J., T.T.C., B.L.R., E.A.A., M.E.L., A.C.G., Y.L., S.C., T.R.C., M.A., M.N.R.), Cedars‑Sinai Health Sciences University, Los Angeles, CA.ORCID 0000-0001-9042-2909
Magali Noval RivasDepartment of Pediatrics, Cedars-Sinai Guerin Children's (A.E.A., P.K.J., T.T.C., B.L.R., E.A.A., M.E.L., A.C.G., Y.L., S.C., T.R.C., M.A., M.N.R.), Cedars‑Sinai Health Sciences University, Los Angeles, CA.ORCID 0000-0001-5570-8928
Funding
Role of intestinal microbiome and gut permeability in the development of Kawasaki Disease vasculitisR01HL139766 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI Magali Noval Rivas · 2018 to 2026
$3.4M
Role of Sex in Immune Stromal cell Interactions driving cardiovascular lesions in Kawasaki Disease vasculitisR01HL170580 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI Moshe Arditi · 2024 to 2026
$1.7M
Targeting the Sirt-1 pathway to modulate inflammation during murine Kawasaki Disease vasculitisR01HL159297 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI NOVAL RIVAS, MAGALI · 2021 to 2024
$1.7M
Role of HMGB1 in an experimental model of Bacterial ligand induced VasculitisR21AI193709 · NIAID · CEDARS-SINAI MEDICAL CENTER · PI ARDITI, MOSHE · 2025 to 2025
backgroundSIRT1 (sirtuin 1), a nicotinamide adenine dinucleotide-dependent protein deacetylase, regulates cardiovascular inflammation by modulating cellular stress, inhibiting NLRP3 (NLR family, pyrin domain-containing 3) activation, and promoting the clearance of damaged mitochondria. However, its precise role in the pathogenesis of Kawasaki disease, a pediatric systemic vasculitis that causes coronary artery aneurysms in children, remains unclear.
methodsUsing the
resultsSIRT1 expression was downregulated in cardiovascular lesions of LCWE-injected mice, which was associated with a significant reduction of circulating levels of nicotinamide. Supplementation of mice with nicotinamide adenine dinucleotide precursors or genetic overexpression of SIRT1 significantly reduced the development of LCWE-induced vasculitis, while the specific deletion of
conclusionsThis study reveals an impaired nicotinamide adenine dinucleotide-SIRT1 axis in the pathogenesis of LCWE-induced vasculitis and the therapeutic potential of targeting this axis to reduce cardiovascular lesions and inflammation.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Sirtuin 1 Activation Mitigates Murine Vasculitis Severity by Promoting Mitophagy. · full record | OpenQuestion