ArticleFrontiers in nutrition2026
Nutritional properties of extracellular vesicle-like particles from
Article in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.
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Corrections and comments
- Erratum issued
Authors and funding
12 authors.
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Abstract
Introduction: The medicinal plant Methods: We separated SF-EVLP and PA-EVLP via ultracentrifugation and characterized them via nano flow cytometry, transmission electron microscopy, and atomic force microscopy. Ultra-high-performance liquid chromatography coupled with mass spectrometry (UPLC/MS) was used to analyze the nutritional content of proteins, lipids, amino acids, phenols, and flavonoids in SF-EVLP and PA-EVLP. Moreover, we comprehensively evaluated the effects of SF-PA-EVLPs on wound healing and related complications in diabetic rats and systematically elucidated the underlying mechanisms. Results: The size of SF-EVLPs and PA-EVLPs was in the nanometer range, and they had a lipid bilayer structure. They contained abundant bioactive substances, lipids, proteins, and nucleic acids. In diabetic rat models, SF-PA-EVLPs had better wound healing effects than PA extract alone and significantly promoted diabetic wound healing. Concurrently, SF-PA-EVLPs had negligible effects on bone formation in streptozotocin-induced diabetic rats while ameliorating pancreatic injury. Moreover, several key substances within SF-PA-EVLPs exhibited significant enrichment in the EGFR signaling pathway with strong binding affinity. Conclusion: At the dosage and treatment duration used in this study, combined therapy with SF-PA-EVLPs had stronger diabetic wound healing effects compared to clinically used PA extracts. Here, we also established the first cross-kingdom modulation system, providing a novel approach for developing nano-nutritional therapeutics based on medicinal plants, edible insects, and foods.
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