Evidence map›Paper›PMID 42137870›Full record

ReviewFrontiers in nutrition2026

Insights into factors governing encapsulation and release performance of starch-based nanocarriers for nutraceuticals delivery.

Youming Zuo, Iris J Joye

Abstract readReview
In one paragraph

Review in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Youming ZuoDepartment of Food Science, University of Guelph, Guelph, ON, Canada.
Iris J JoyeDepartment of Food Science, University of Guelph, Guelph, ON, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Starch-based nanocarriers offer a versatile platform for enhancing the stability and bioavailability of labile nutraceuticals. Their performance, however, is highly sensitive to complex interacting variables, constraining rational design. This review systematically analyzes the critical factors governing encapsulation efficiency and release kinetics to establish factor-property-function correlations. Key findings reveal that carrier performance is not determined by a single variable but by the synergistic interplay of colloidal properties (particle size, PDI, zeta potential), material structure (crystallinity, amylose/amylopectin ratio), and preparation methods. Furthermore, the intrinsic properties of bioactive compounds (solubility, size, charge) are identified as primary drivers that dictate the binding and retention mechanisms. Consequently, a bioactive-driven rational design strategy is proposed, suggesting that carrier type should be precisely tailored to the specific cargo. This review provides essential guidance for the development of high-performance starch-based delivery systems for nutraceuticals. Future research should focus on precise structural modulation and performance verification within complex food matrices to bridge the gap between laboratory design and industrial application.

Indexed as

bioactive compoundencapsulation efficiencynutraceuticalrelease performancestarch-based nanocarrier

Identifiers

PMID42137870
PMCPMC13167446

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.